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Semax
Semax 5mg/10mg – ACTH(4-10) analogue neuropeptide for research
Peptology Ltd. · Peptides for immunity and hormonal balance
Semax 5 mg/10 mg – a synthetic heptapeptide analogue of ACTH(4-10) with a Pro-Gly-Pro sequence at the C-terminus; a nootropic research peptide studied in Russia. Purity 99%+, HPLC/MS report for every batch.
📦 The product is in our EU warehouse – delivery within 3–5 working days.
30,00 € · In stock
- 5mg — 30,00 €
- 10mg — 45,00 €
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 / 0126 |
What is Semax (5 mg / 10 mg)?
Semax is a synthetic nootropic neuropeptide — an analog of a fragment of adrenocorticotropic hormone (ACTH 4-7). Importantly, it does not exhibit ACTH-type hormonal activity, but rather strong nootropic, neuroprotective and antidepressant action. In the research literature it is associated with improved memory, concentration and learning, and with regeneration of the nervous system.
Semax was developed in Russia and studied clinically there (including in ischemic and neurological conditions). In the Peptology catalog it belongs to the category peptides for immunity and hormonal balance — as a „brain" peptide with neuroendocrine and immunomodulatory action, alongside the related nootropic Selank.
It is a research compound — in the EU it is not a registered medicinal product. The product offered by Peptology is a research-grade reagent, not intended to diagnose or treat any neurological conditions.
Semax is available in two dose variants — 5 mg and 10 mg — as a lyophilized peptide of high purity, confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.
How Semax works — a neuroprotective mechanism
In the research literature, Semax is described as a neuropeptide that modulates several brain pathways. Below are the three most frequently studied elements.
BDNF / NEUROPLASTICITY
Stimulates the production of BDNF (a neurotrophic factor) — key for neuroplasticity and the repair of connections.
DOPAMINE / SEROTONIN
Modulates neurotransmitters (especially dopamine and serotonin) — an influence on mood, concentration and motivation.
NEUROPROTECTION
Protective action under conditions of hypoxia and stress, plus antioxidant/anti-inflammatory effects.
Why „an ACTH analog without hormonal action"
Semax is derived from a fragment of ACTH (4-7), but it has been modified so that it retains neurotropic effects while losing hormonal activity (it does not stimulate the adrenal axis like full ACTH). This makes it a „pure" nootropic/neuroprotector — it acts on the brain, not on cortisol metabolism. In studies it is used, among other things, in the context of cognitive fatigue and recovery after stroke.
The second „brain" peptide in the catalog is Selank (with a more anxiolytic profile). These data come from the research literature and do not constitute a claim about the effect of the research-grade product offered by Peptology.
Pharmacokinetics and pharmacodynamics (research framework)
Semax is a short neuropeptide with a rapid onset of action. The most important research features:
- Class: synthetic neuropeptide, analog of ACTH (4-7) without hormonal activity
- Targets: ↑ BDNF, modulation of dopamine/serotonin, neuroprotection
- Onset of action: cognitive effects observed within ~30–60 min
- Route of administration in protocols: parenteral (subcutaneous/intramuscular) or intranasal; doses on the order of 300–600 µg/day in 2–3 administrations
- Schedule: courses of 5–10 days with 1–2 week breaks (described in the literature)
- Profile: good tolerability, no ACTH hormonal action
Variant comparison: Semax 5 mg vs 10 mg
Semax is available in two doses. Both variants are the same peptide — the difference concerns only the amount of substance in the vial, which translates into the scale and length of the research protocol.
| Semax 5 mg | Semax 10 mg | |
|---|---|---|
| Amount of peptide | 5 mg | 10 mg |
| Peptide | Semax (ACTH 4-7) | Semax (ACTH 4-7) |
| Purity | High (CoA per batch) | High (CoA per batch) |
| Protocol scale | Smaller / shorter | Larger / longer |
| Best for | Initial / shorter research series | Extended protocols / economy of scale |
Both variants are the same high-purity peptide — the difference concerns only the amount in the vial. The choice depends on the scale of the planned protocol. Regardless of the variant, it is worth adding Peptide Matrix Water™ for reconstitution.
Comparison: Semax vs Selank vs Thymosin Alpha-1
Within the same category it is worth comparing Semax with two other peptides — the nootropic-anxiolytic Selank and the immunomodulatory Thymosin Alpha-1. Semax and Selank are two „brain" peptides; Thymosin shows the immunological pole of the category.
| Semax (this page) | Selank | Thymosin Alpha-1 | |
|---|---|---|---|
| Main research area | Cognitive functions, neuroprotection | Anxiety, mood, nootropic | Immunity (T/NK cells) |
| Mechanism | ↑ BDNF, dopamine/serotonin | Serotonin / GABA modulation | Immunomodulation |
| Profile | Cognitive stimulation, concentration | Calming, anxiety reduction | Immune support |
| Dose (variants) | 5 / 10 mg | 5 mg | 5 / 10 mg |
| Best for research on | Memory and concentration | Anxiety and mood | Immunity |
Semax stimulates cognitive functions (BDNF, dopamine), Selank calms and acts anxiolytically, and Thymosin Alpha-1 supports immunity. In studies, Semax and Selank are sometimes combined as a nootropic pair. This comparison is indicative in nature and does not constitute a recommendation for use.
Research areas for Semax
Semax is a well-described nootropic neuropeptide, studied (including clinically in Russia) for decades. Below are the most frequently explored directions.
Cognitive functions and mood
The main direction of research on Semax concerns improved memory, concentration and learning and reduced mental fatigue — through BDNF stimulation and modulation of dopamine/serotonin.
Neuroprotection (ischemia, stroke)
Semax has been studied in the context of ischemic stress and recovery after stroke or brain injury.
Neuroplasticity (BDNF)
BDNF stimulation links Semax with research on neuroplasticity and the rebuilding of neuronal connections. These are research directions, not confirmed applications of the research-grade product.
Note: The information is presented for scientific and informational purposes and is based on the research literature. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.
Semax profile at a glance
- Nootropic neuropeptide (ACTH 4-7 analog) — without hormonal activity, „brain" action
- BDNF stimulation and modulation of dopamine/serotonin — memory, concentration, mood
- Neuroprotection under conditions of hypoxia and stress (studies, including after stroke)
- Two variants: 5 mg (initial series) and 10 mg (extended protocols)
- The second „brain" peptide in the catalog: Selank (anxiolytic)
- Every batch with CoA and confirmed laboratory purity
All information provided concerns research literature on Semax and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology.
Research dosing protocols
Important: The information below describes schedules used in research on Semax. It is provided for scientific and informational purposes and does not constitute a recommendation for individual use, medical advice or administration instructions. The research-grade Semax offered by Peptology is not a registered medicine in the EU.
In research protocols, Semax is usually administered after reconstitution of the lyophilizate, parenterally (subcutaneously/intramuscularly) or intranasally:
- Described doses on the order of 300–600 µg/day in 2–3 administrations
- Courses usually 5–10 days, with 1–2 week breaks
- Cognitive effects observed quickly (~30–60 min)
- Calculate precise volumes and units in the peptide calculator (max. 3 mL of solvent per vial)
In combination protocols, Semax is sometimes combined with the anxiolytic Selank (a nootropic pair). These schedules come from the research literature and do not constitute a recommendation for self-administration.
Side effects and safety
In research observations, Semax is described as well tolerated, without systemic hormonal effects. Side effects are rare and mild. The data concern research on the molecule.
Rare (mild)
- Mild irritation of the nasal mucosa (intranasal form)
- Headache at higher doses
Tolerability profile
- Good tolerability in observations
- No ACTH hormonal action
- Safe in the described long-term use
To consider
- Consultation for long-term use
- No registration in the EU
- Hypersensitivity to components
Most reported symptoms are mild and transient, and Semax exhibits no ACTH hormonal action. This information is scientific in nature and does not constitute an instruction for use.
Storage and reconstitution
Semax is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.
- Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
- After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
- After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
- Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
- Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
- Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.
Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.
Frequently asked questions about Semax
What exactly is Semax?
It is a synthetic nootropic neuropeptide — an analog of a fragment of ACTH (4-7) without hormonal activity. In research it is associated with improved memory, concentration and neuroprotection through BDNF stimulation and modulation of dopamine/serotonin.
How quickly does Semax work?
In observations, effects (concentration, clarity of thinking, mood) appear within ~30–60 minutes of administration. These are research data, not a claim about the effect of the research-grade product.
How does it differ from Selank?
Semax is more „cognitively stimulating" (BDNF, dopamine — memory/concentration), while Selank has a more anxiolytic profile (calming, anxiety reduction). They are two complementary „brain" peptides.
Does Semax act like the ACTH hormone?
No. Although it is derived from a fragment of ACTH (4-7), it has been modified so that it retains neurotropic effects but does not exhibit hormonal activity (it does not stimulate the adrenal axis or cortisol).
How is Semax stored and reconstituted?
The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.
Where to buy Semax for research?
Peptology offers Semax (5 mg / 10 mg) as a research peptide of confirmed purity with independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.
Related products in the Peptology catalog
Researchers working with Semax often also consider related „brain" peptides and compounds of the immunity/hormone axis. Each of the products below has a certificate of purity (CoA):
Selank
Nootropic-anxiolytic peptide (paired with Semax)
Thymosin Alpha-1
Immunostimulatory peptide (T/NK cells)
Thymulin
Neuroimmunological modulator
Gonadorelin
GnRH agonist — hormonal axis
KPV
Anti-inflammatory peptide — immunity and gut
Peptide Matrix Water™
Stabilizing solution for reconstitution
See the full catalog: Peptides for immunity and hormonal balance · Peptides for skin, sleep and libido · Peptides for energy and regeneration · Blog on peptide research
Research warning: Semax is offered exclusively for scientific research and in vitro purposes. It is not a medicinal product in the EU, is not approved for use in humans or animals, and does not replace medical advice. All information comes from research literature and is provided for scientific and informational purposes; it does not constitute a claim about the effect of the product.
Laboratory reconstitution
Laboratory protocol — reconstitution, research protocols, storage
Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.
60-second protocol
1. SOLVENT
2. RECONSTITUTION
Add the solvent down the side of the vial, without shaking, wait 10–15 min.
3. CALCULATION
Calculator → concentration mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilized powder |
| Solvent | Peptide Matrix Water |
| Reconstitution volume | 1–3 mL — maximum 3 mL (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration not required) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you need
Precision pipette
Calibrated, 100–1000 µL — for accurately measuring the volume of solvent added to the vial.
70% alcohol swabs
Two swabs — to disinfect the peptide vial and the solvent vial.
Stabilized solvent for lyophilized peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Mistake |
|---|---|
| Disinfect the vial caps and the work surface with 70% alcohol; wear gloves | Working without disinfection |
| Add the solvent slowly along the vial wall | Direct jet onto the powder — foaming and denaturation |
| Gentle rolling between the palms | Shaking — foam, which denatures peptides |
| 10–15 minutes waiting at room temperature | Mechanical mixing or heating |
| Visual check: clear, particle-free | Working with a cloudy or discolored solution |
Calculating concentration
⚠️ Maximum 3 mL solvent. The standard vial does not accommodate larger volumes — do not exceed during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after adding the solvent (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in original packaging. Refrigerator not required.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard any remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade peptide structure.
Four mistakes to avoid
1. Shaking "to dissolve faster"
Foam = denaturation. Only gentle rolling between the palms.
2. Inappropriate solvent
For peptide stability use only sterile, specially formulated solvent — recommended Peptide Matrix Water.
3. Ignoring slight turbidity
Not fully clear = the sample does not meet the criteria for use.
4. Taking it out of the refrigerator "for an hour–two"
Short exposures add up and compromise stability.
Research status: All Peptology products are intended for laboratory and research use only. They are not medicinal products, not approved for human or veterinary use and do not substitute medical advice. The described protocol is standard laboratory practice for working with lyophilized peptides.
Shipping information
🚚 Shipping information
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Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.
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Delivery with GLS to your address in 3–5 working days.
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Shipping costs €5 and is free from €50.
Frequently Asked Questions (FAQ)
In what form is Semax supplied and how should it be stored?
It is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store the unopened vial dry and protected from light, ideally at 2–8 °C. After laboratory reconstitution, keep the solution at 2–8 °C and use it within the period stated in the “Laboratory reconstitution” tab (up to 60 days with Peptide Matrix Water).
What purity does Semax have and how is it tested?
Every batch has a purity of 99% or higher, confirmed by HPLC and mass spectrometry (MS) and documented in a certificate of analysis (CoA). The report for the current batch is shown in the “Laboratory Analysis” tab.
Is a prescription required?
No – the product is supplied for research use only.
Where can I buy Semax in Europe and what does it cost?
You can buy Semax in Europe online from Peptology, from 30,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.
Laboratory Analysis
Semax - 5mg - Batch - 0126 - Purity
Semax - 10mg - Batch - 0226 - Purity
