SS-31 10 mg / 50mg – Mitochondria-targeted antioxidant peptide

What is SS-31 (10 mg / 50 mg)?

SS-31 (research name Elamipretide) is a synthetic mitochondria-targeted tetrapeptide with the sequence D-Arg-dimethylTyr-Lys-Phe-NH2. Its distinguishing feature is that it binds directly to cardiolipin — a key lipid of the inner mitochondrial membrane — stabilizing the mitochondria, supporting ATP production and reducing oxidative stress.

SS-31 belongs to the category peptides for energy and regeneration and is one of the most frequently studied mitochondrial peptides. Unlike the coenzyme NAD+, which fuels energy metabolism from the side of enzymatic reactions, SS-31 acts structurally — at the level of the mitochondrial membrane.

In the version offered by Peptology, SS-31 is available in two dose variants — 10 mg and 50 mg — as a lyophilized peptide with purity above 99% (HPLC/MS), confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.

How SS-31 works — the mitochondrial mechanism

In the research literature, SS-31 is described as a peptide that „targets" the mitochondria. Below are the three most frequently studied elements of its mechanism.

Why cardiolipin is key

Cardiolipin is a lipid that gives the inner mitochondrial membrane its characteristic shape and is essential for the proper functioning of the respiratory chain. When it is damaged (e.g. in oxidative stress), the efficiency of energy production drops. By binding to cardiolipin, SS-31 is studied as a compound stabilizing this system — hence the interest in it in contexts related to mitochondrial function.

In studies, SS-31 is sometimes combined with the coenzyme NAD+ (metabolic energy) and repair peptides like BPC-157. These data come from preclinical and clinical research on Elamipretide and do not constitute a claim about the effect of the research-grade product offered by Peptology.

Pharmacokinetics and pharmacodynamics (research framework)

SS-31 is a small, stable tetrapeptide with an affinity for mitochondrial membranes. The most important research features:

• Structure: synthetic tetrapeptide D-Arg-dimethylTyr-Lys-Phe-NH2 (Elamipretide)
• Target: cardiolipin of the inner mitochondrial membrane
• Penetration: crosses cell membranes and accumulates in the mitochondria independently of the membrane potential
• Profile: in clinical trials Elamipretide was described as well tolerated
• Route of administration in protocols: most often subcutaneous, per the research protocol
• Form: lyophilized powder for reconstitution (10 mg and 50 mg variants)

Variant comparison: SS-31 10 mg vs 50 mg

SS-31 is available in two doses. Both variants are the same peptide with purity > 99% — the difference concerns only the amount of substance in the vial, which translates into the scale and length of the research protocol.

Both variants contain the identical, certified peptide with purity > 99% — the difference concerns only the amount in the vial. The choice depends on the scale of the planned research protocol. Regardless of the variant, it is worth adding Peptide Matrix Water™ for reconstitution.

Comparison: SS-31 vs other peptides from the energy and regeneration category

Beyond the dose variants, it is worth comparing SS-31 with two other peptides from the same category — BPC-157 and TB-500. Each of them addresses a different mechanism, which is why in research protocols they are sometimes used side by side rather than interchangeably.

SS-31 occupies a unique niche in this group — it is the only one that acts directly at the mitochondrial level. The repair peptides BPC-157 and TB-500 are also available as a ready-made complex BB20. This comparison is indicative in nature and does not constitute a recommendation for use.

Research data on SS-31 / Elamipretide

Elamipretide is one of the few mitochondrial peptides also studied in clinical settings. Below are the most important directions — all at the research stage, without approved indications.

Mitochondrial function and energy

In preclinical models, SS-31 is associated with improved mitochondrial efficiency and ATP production and reduced oxidative stress — which makes it a subject of research on muscle fatigue and energy metabolism.

Clinical trials (Elamipretide)

Elamipretide has been the subject of clinical trials in areas such as mitochondrial diseases and selected cardiological and ophthalmic conditions. The early phases were described as well tolerated, but the compound did not obtain the status of an approved medicine — the studies remain ongoing, and some ended with inconclusive results.

Neuroprotection and regeneration

Because of the role of mitochondria in nerve cells, SS-31 is also studied in the context of neuroprotection and regeneration. These are research directions, not confirmed therapeutic applications.

Note: The information is presented for scientific and informational purposes and is based on the preclinical literature and research on Elamipretide. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.

SS-31 profile at a glance

• Tetrapeptide targeting the mitochondria — binds the cardiolipin of the inner mitochondrial membrane
• Three studied effects: cardiolipin stabilization, support for ATP production, ROS reduction
• Two variants: 10 mg (initial series) and 50 mg (extended protocols)
• Complementary with NAD+ — metabolic energy + membrane stabilization
• Studied clinically as Elamipretide, but not approved as a medicine — the research-grade product is not a medication
• Every batch with CoA and purity > 99% (HPLC/MS)

All information provided concerns research literature on SS-31 / Elamipretide and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology.

Research dosing protocols

In research protocols, SS-31 is usually administered after reconstitution of the lyophilizate, most often subcutaneously:

• The schedule is usually daily, in cycles on the order of a few weeks, per the protocol
• The 10 mg variant works well for initial, shorter series; 50 mg for extended protocols
• Calculate the precise concentration and volume in the peptide calculator (maximum 3 mL of solvent per vial)

In combination protocols, SS-31 is sometimes combined with the coenzyme NAD+ (metabolic energy) and repair peptides like BPC-157 and TB-500. These schedules come from the research literature and do not constitute a recommendation for self-administration.

Side effects and safety

In clinical trials, Elamipretide was described as well tolerated. The reported side effects were usually rare, mild and transient. The data concern research on the molecule, not the research-grade product.

Most reported symptoms are mild and transient. This information is scientific in nature and does not constitute an instruction for use or a claim about the safety of the research product.

Storage and reconstitution

SS-31 is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.

• Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
• After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
• After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
• Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
• Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
• Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.

Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.

Frequently asked questions about SS-31

What exactly is SS-31?

It is a synthetic tetrapeptide (Elamipretide) targeting the mitochondria. It binds to the cardiolipin of the inner mitochondrial membrane and is studied for mitochondrial stabilization, support for ATP production and reduction of oxidative stress. The results come from the research literature.

Is SS-31 the same as the medicine Elamipretide?

SS-31 and Elamipretide are the same molecule, but the product offered by Peptology is a research reagent (research-grade), not a medicine. Elamipretide was studied clinically, but it is not an approved medicinal product in the EU.

Which vial size to choose — 10 mg or 50 mg?

Both variants are the same peptide with purity > 99% — they differ in the amount in the vial. The 10 mg variant works well for initial or shorter research series, and 50 mg for extended protocols and economy of scale.

How does SS-31 differ from NAD+?

Both concern cellular energy, but they act differently. SS-31 is a peptide acting structurally on the mitochondrial membrane (cardiolipin); NAD+ is a coenzyme that fuels metabolic reactions. In studies they are sometimes combined as complementary.

How is SS-31 stored and reconstituted?

The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.

Where to buy SS-31 for research?

Peptology offers SS-31 (10 mg / 50 mg) as a research peptide with confirmed purity above 99% and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.

Related products in the Peptology catalog

Researchers working with SS-31 often also consider related compounds from the area of cellular energy and regeneration. Each of the products below has a certificate of purity above 99%:

See the full catalog: Peptides for energy and regeneration · Recovery and anabolic peptides · Solutions for peptides · Blog on peptide research

Molecule identity

Laboratory reconstitution

Laboratory protocol — reconstitution, research protocols, storage

Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.

60-second protocol

Quick reference

What you need

Five rules for reconstitution

Calculating concentration

Storage

Four mistakes to avoid

Shipping information

🚚 Shipping information

• Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.

• Delivery with GLS to your address in 3–5 working days.

• Shipping costs €5 and is free from €50.

Frequently Asked Questions (FAQ)

What makes SS‑31 different from other peptides?

It targets mitochondria directly and stabilizes cardiolipin – a key component for cellular energy and longevity.

In what form is SS-31 supplied and how should it be stored?

It is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store the unopened vial dry and protected from light, ideally at 2–8 °C. After laboratory reconstitution, keep the solution at 2–8 °C and use it within the period stated in the “Laboratory reconstitution” tab (up to 60 days with Peptide Matrix Water).

Is a prescription required?

No. The product is for laboratory and research use only.

Where can I buy SS‑31 in Europe and what does it cost?

You can buy SS‑31 in Europe online from Peptology, from 69,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.

Laboratory Analysis

SS-31 - 10mg - Batch - 0226 - Purity

SS-31 - 50mg - Batch - 0226 - Purity