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BPC‑157
BPC-157 5 mg/10mg – Synthetic pentadecapeptide for laboratory research
Peptology Ltd. · Recovery and anabolic peptides
BPC‑157 – a synthetic pentadecapeptide (15 amino acids), a fragment of the gastric protective protein BPC (Body Protection Compound); research peptide. Purity 99%+, HPLC/MS report for every batch.
📦 The product is in our EU warehouse – delivery within 3–5 working days.
25,00 € · In stock
- 5mg — 25,00 €
- 10mg — 45,00 €
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide — a chain of 15 amino acids that is a fragment of a natural protective protein (BPC), discovered in gastric juice. In the research literature it is described as one of the most potent regenerative peptides, targeted at the healing of tissues, tendons, muscles and the intestinal mucosa and at cytoprotection.
BPC-157 belongs to a different class than the GH-axis peptides. Molecules such as CJC-1295 or Ipamorelin stimulate the secretion of growth hormone, and IGF-1 LR3 drives hypertrophy. BPC-157 acts differently — it supports angiogenesis and protects cells, accelerating tissue repair and regeneration of the intestinal barrier. That is why in studies it is often combined with TB-500 as a complementary regenerative pair.
BPC-157 is studied in the context of the healing of tendons, ligaments and muscles, gastroprotection (stomach, intestines), modulation of inflammation and neuroprotection. It is a research peptide — it holds no registration as a medicinal product in the EU. It belongs to the category recovery and anabolic peptides.
In the version offered by Peptology, BPC-157 is supplied as a lyophilized peptide with purity above 99% (HPLC/MS), confirmed by independent laboratory analysis (CoA for every batch). It is available in two vial formats — 5 mg and 10 mg — depending on the scale of the research protocol.
Available formats: 5 mg and 10 mg
BPC-157 is available in two lyophilized formats that cover different scales of research work — from single in vitro series to longer regenerative protocols with higher peptide consumption.
5 MG
Standard format
Suitable for validation experiments, single in vitro series and shorter regenerative protocols.
10 MG
Enlarged format
For longer research series, tissue-repair models and protocols with higher peptide consumption.
Both formats have identical purity > 99% and the same laboratory certificate for the batch. The choice of size depends on the scale of the protocol, not on the concentration of the active substance.
How BPC-157 works — angiogenesis and cytoprotection
In the research literature, BPC-157 is described as a molecule acting through several complementary repair mechanisms. Their common denominator is the rebuilding of blood supply, the protection of cells and the acceleration of healing of damaged tissues.
ANGIOGENESIS (VEGFR2)
Increases VEGF expression and activates the VEGFR2 pathway and the Akt-eNOS axis — it stimulates the formation of new vessels and improves the blood supply of the healing tissue.
CYTOPROTECTION & GUT
Derived from a gastroprotective protein — in studies it protects the mucosa of the stomach and intestines and supports the intestinal barrier and NO homeostasis.
TISSUE REPAIR
Stimulates the migration of fibroblasts (the FAK-paxillin pathway) and collagen synthesis — it accelerates the healing of tendons, ligaments and muscles.
Why the „body protection compound" matters
BPC-157 stands out for its broad, „protective" profile: it does not target a single receptor, but supports several repair mechanisms at once — angiogenesis, cytoprotection and cell migration. The original studies focused on protecting the gastrointestinal tract (stomach, duodenum), and subsequent ones expanded the scope to tendons, ligaments, muscles and even the nervous system. A central element is the interaction with the nitric oxide (NO) system, which BPC-157 helps to keep in balance across various injury models.
This mechanism is complementary to TB-500, which acts mainly through actin regulation and cell migration — which is why the two peptides are often studied together. These data come from preclinical studies and do not constitute a claim about the effect of the research-grade product.
Pharmacokinetics and pharmacodynamics of BPC-157
BPC-157 has a characteristic profile: a short presence in plasma, but biological effects lasting from days to weeks — this is the so-called „PK/PD disconnect", typical of this molecule.
- Plasma half-life: short — below 30 minutes in animal pharmacokinetic data
- Effects lasting days–weeks: the triggered cascades (VEGFR2, FAK-paxillin, the NO system) act long after the peptide has been cleared
- Metabolism: hepatic; renal clearance
- Stability: described as stable — studied after both injectable and oral administration
- Target: multidirectional — angiogenesis, cytoprotection, cell migration (not a single receptor)
- Human data: to date no published pharmacokinetic studies in humans
BPC-157 vs TB-500 vs IGF-1 LR3
The table below compares the three most frequently studied „regenerative" peptides with different mechanisms. BPC-157 acts cytoprotectively and pro-angiogenically, TB-500 regulates actin and cell migration, and IGF-1 LR3 drives growth and hypertrophy. Because their mechanisms are complementary, in studies they are sometimes combined into a „regenerative stack". The data are scientific and comparative in nature.
| BPC-157 | TB-500 | IGF-1 LR3 | |
|---|---|---|---|
| Class | Cytoprotective pentadecapeptide | Thymosin beta-4 fragment | IGF-1 analog (growth factor) |
| Main mechanism | Angiogenesis, cytoprotection | Actin regulation, cell migration | Protein synthesis, hypertrophy |
| Main research area | Tendons, ligaments, GI tract | Wound healing, soft tissues | Muscle growth and regeneration |
| Half-life | < 30 min (effects longer) | ~2–3 h (effects longer) | ~20–30 h |
| Role in the regenerative „stack" | Protection and blood supply of tissues | Migration and tissue repair | Anabolism |
The values and properties are approximate and come from the literature on regenerative peptides. The table is scientific and comparative in nature and does not constitute a direct head-to-head comparison or a claim about the effect of the research-grade product.
Research data on BPC-157
BPC-157 is widely studied in preclinical models (mainly rodents); to date no controlled clinical trials in humans have been published. Below are the most important directions from the literature.
Healing of tendons, muscles and ligaments
The best-documented area is the repair of the musculoskeletal system. In animal models, BPC-157 is associated with faster healing of tendons, ligaments, muscles and tendon-muscle junctions — largely thanks to the stimulation of angiogenesis and fibroblast migration.
Gastroprotection and the intestinal barrier
The original direction of research on BPC-157 concerned protection of the gastrointestinal tract. In models of mucosal damage (including that induced by ethanol or stress), the peptide exhibited a protective action on the stomach and duodenum and supported the integrity of the intestinal barrier.
Neuroprotection and the NO system
Some studies point to the neuroprotective potential of BPC-157 and to its role in maintaining nitric oxide (NO) homeostasis in various injury models. These directions remain the subject of further preclinical research.
Note: The information is presented for scientific and informational purposes and is based on the preclinical literature. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.
BPC-157 profile at a glance
- „Body protection compound" pentadecapeptide — a regenerative peptide with a broad, protective profile
- Stimulates angiogenesis via VEGFR2 and the Akt-eNOS axis — rebuilding the blood supply of the healing tissue
- Cytoprotection of the gastrointestinal tract — derived from a gastroprotective protein of gastric juice
- Accelerates the healing of tendons, ligaments and muscles in preclinical models
- Short half-life, long effects — it triggers cascades acting for days–weeks
- Complementary to TB-500 — a classic pair in regeneration research
All information provided concerns preclinical literature on BPC-157 and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology.
Research dosing protocols
Important: The information below describes schedules used in research on BPC-157. It is provided for scientific and informational purposes and does not constitute a recommendation for individual use, medical advice or administration instructions. The research-grade BPC-157 offered by Peptology is not a registered medicine.
In the research literature, BPC-157 is described in schedules with daily administration, usually in shorter cycles targeted at regeneration:
- Subcutaneous administration (often near the injury site in models) or — in some studies — oral
- Schedule usually daily, in cycles on the order of 2–4 weeks (up to ~6 weeks in chronic models)
- Despite the short half-life, effects last longer — thanks to the triggered repair cascades
- Combination schedules: BPC-157 + TB-500 (complementary mechanisms) or with GH-axis peptides
In regenerative protocols, BPC-157 is sometimes combined with TB-500, and in GH-axis protocols with CJC-1295 or Ipamorelin. These schedules come from the research literature and do not constitute a recommendation for self-administration.
Side effects and safety
In preclinical models, BPC-157 is described as exceptionally well tolerated — with a very high safety profile and rare, mild side effects. It should be remembered, however, that there are no data from clinical trials in humans.
Rare and mild
- Mild discomfort at the injection site
- Transient fatigue
- Nausea at higher doses
Tolerability profile
- Very good tolerability in models
- No serious side effects reported
- Stable after injectable and oral administration
To consider
- Pro-angiogenic action — caution in proliferation contexts
- No clinical data in humans
- Hypersensitivity to formula components
Most observed side effects are mild and transient. As a pro-angiogenic peptide, BPC-157 requires caution in contexts related to cell proliferation. This information is scientific in nature and does not constitute an instruction for use.
Storage and reconstitution
BPC-157 is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.
- Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
- After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
- After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
- Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
- Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
- Homogenization: add the solvent slowly down the vial wall, without vigorous shaking — peptide bonds are sensitive to mechanical stress. Swirl gently, do not shake.
Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.
Frequently asked questions about BPC-157
What exactly is BPC-157?
It is a synthetic pentadecapeptide (15 amino acids) that is a fragment of a protective protein from gastric juice. In studies it supports angiogenesis, protects cells and accelerates tissue repair — of tendons, muscles, ligaments and the intestinal mucosa. The results come from the preclinical literature.
How does BPC-157 differ from TB-500?
Both are regenerative peptides, but they act differently. BPC-157 acts cytoprotectively and pro-angiogenically (rebuilding blood supply, protecting tissues), while TB-500 regulates actin and cell migration. Their mechanisms are complementary, which is why they are often combined into a pair in studies.
What is the half-life of BPC-157?
Short — below 30 minutes in animal data. What is characteristic, however, is the „PK/PD disconnect": despite the rapid clearance of the peptide from plasma, the repair cascades it triggers (angiogenesis, fibroblast migration) act for days to weeks.
Which format to choose — 5 or 10 mg?
Both have identical purity > 99% and the same batch certificate. 5 mg works well for shorter protocols and single series, and 10 mg — for longer tissue-repair models with higher peptide consumption.
Can it be combined with other peptides?
Yes — it is classically combined with TB-500 for a complementary regenerative effect, and also with GH-axis peptides (CJC-1295, Ipamorelin).
How is BPC-157 stored and reconstituted?
The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.
Where to buy BPC-157 for research?
Peptology offers BPC-157 (5 / 10 mg) as a research peptide with confirmed purity above 99% (HPLC/MS) and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.
Related peptides in the Peptology catalog
Researchers working with BPC-157 often also consider other regenerative peptides and GH-axis tools that complement its action. Each of the products below has a certificate of purity above 99%:
TB-500
A complementary regenerative peptide
IGF-1 LR3
Anabolic growth factor
CJC-1295 without DAC
GHRH analog (GH axis)
Ipamorelin
Selective GH secretagogue
CJC-1295 + Ipamorelin
Ready-made GH-axis complex
Peptide Matrix Water™
Stabilizing solution for reconstitution
See the full catalog: Recovery and anabolic peptides · Solutions for peptides · Blog on peptide research
Research warning: BPC-157 is offered exclusively for scientific research and in vitro purposes. It is not a medicinal product, is not approved for use in humans or animals, and does not replace medical advice. All information comes from the preclinical literature and is provided for scientific and informational purposes; it does not constitute a claim about the effect of the research-grade product offered by Peptology.
Laboratory reconstitution
Laboratory protocol — reconstitution, research protocols, storage
Standardized protocol valid for all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.
60-second protocol
1. SOLVENT
2. RECONSTITUTION
Add the solvent against the vial wall, do not shake, wait 10–15 minutes.
3. CALCULATION
Calculator → concentration mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilized powder |
| Solvent | Peptide Matrix Water |
| Volume for reconstitution | 1–3 mL — maximum 3 mL (capacity of a standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration not required) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you need
Precision pipette
Calibrated, 100–1000 µL — for accurately measuring the volume of solvent added to the vial.
70% alcohol swabs
Two swabs — to disinfect the peptide vial and the solvent vial.
Stabilised solvent for lyophilized peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Incorrect |
|---|---|
| Disinfect the vial caps and the work surface with 70% alcohol; wear gloves | Working without disinfection |
| Add the solvent slowly against the vial wall | Direct jet onto the powder — foaming and denaturation |
| Gentle rolling between the palms | Shaking — foam that denatures peptides |
| 10–15 minutes wait at room temperature | Mechanical stirring or heating |
| Visual check: clear, particle-free | Working with cloudy or coloured solution |
Calculating concentration
⚠️ Maximum 3 mL solvent. The standard vial does not hold a larger volume — do not exceed when reconstituting.
- Concentration (mg/mL) = mg in the vial ÷ mL solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after adding the solvent (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in original packaging. Refrigeration not required.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard any remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade peptide structure.
Four mistakes to avoid
1. Shaking “to dissolve faster”
Foam = denaturation. Only gentle rolling between the palms.
2. Unsuitable solvent
For peptide stability use only a sterile, specially formulated solvent — recommended Peptide Matrix Water.
3. Ignoring slight cloudiness
Not fully clear = the sample does not meet criteria for use.
4. Removing from the refrigerator “for an hour–two”
Short periods out accumulate and compromise stability.
Research status: All products from Peptology are intended for laboratory and research use only. They are not medicinal products, are not approved for human or veterinary use and do not replace medical advice. The described protocol is standard laboratory practice for working with lyophilized peptides.
Shipping information
🚚 Shipping information
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Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.
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Delivery with GLS to your address in 3–5 working days.
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Shipping costs €5 and is free from €50.
Frequently Asked Questions (FAQ)
In what form is BPC-157 supplied and how should it be stored?
It is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store the unopened vial dry and protected from light, ideally at 2–8 °C. After laboratory reconstitution, keep the solution at 2–8 °C and use it within the period stated in the “Laboratory reconstitution” tab (up to 60 days with Peptide Matrix Water).
What purity does BPC-157 have and how is it tested?
Every batch has a purity of 99% or higher, confirmed by HPLC and mass spectrometry (MS) and documented in a certificate of analysis (CoA). The report for the current batch is shown in the “Laboratory Analysis” tab.
Is a prescription required?
No – the product is offered for research use only.
Where can I buy BPC‑157 in Europe and what does it cost?
You can buy BPC‑157 in Europe online from Peptology, from 25,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.
Laboratory Analysis
BPC 157 - 5mg - Batch - 0226 - Purity
BPC 157 - 10mg - Batch - 0226 - Purity
