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SLU-PP-332
SLU-PP-332 5 mg – synthetic ERRα/β/γ agonist for metabolic research
Peptology Ltd. · Peptides for energy and regeneration
SLU-PP-332 5 mg – pan-ERR agonist (exercise-mimetic) for metabolic and mitochondrial research. Reconstitution 1 mL BAC → 5 mg/mL; convenient calculation of working volumes. Efficacy/safety data are preclinical.
📦 The product is in our EU warehouse – delivery within 3–5 working days.
75,00 € · Out of stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 18/10/2026
What is SLU-PP-332 (5 mg)?
SLU-PP-332 is a synthetic, small-molecule agonist of the ERR receptors (ERRα/β/γ), with a preference for ERRα. In the research literature it is described as an "exercise mimetic": activation of the ERR network improves mitochondrial function, oxidative metabolism and energy expenditure — effects similar to aerobic training, observed in mice and in cellular systems.
A clarification is worthwhile: SLU-PP-332 is not a peptide, but a small molecule (a nuclear receptor agonist). In the Peptology catalog it is assigned to the category peptides for skin, sleep and libido because of its application area; functionally, however, it belongs to the group of metabolic and mitochondrial compounds — alongside the AMPK activator AICAR and the mitochondrial peptide MOTS-c.
It is a research compound — it is not a medicinal product and holds no authorization for clinical use. It must be clearly emphasized: no clinical trials in humans have been conducted — all efficacy and safety data come from preclinical models. The product offered by Peptology is a research-grade reagent.
In the version offered by Peptology, SLU-PP-332 is available in a 5 mg vial as a lyophilized powder with purity ≥ 99%, confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.
Variant: SLU-PP-332 5 mg
This page concerns one dosage variant — SLU-PP-332 5 mg. Each vial contains 5 mg of the lyophilized compound. A typical working reconstitution is 1 mL → 5 mg/mL, which makes it easier to measure working volumes precisely in a metabolic protocol.
VIAL · 5 MG
SLU-PP-332 (ERR agonist)
5 mg of lyophilized compound, purity ≥ 99% confirmed by CoA for every batch.
REFERENCE CONCENTRATION
5 mg/mL (at 1 mL)
Typical working reconstitution. Calculate volumes in the calculator.
SLU-PP-332 is offered in the 5 mg variant. Other "exercise-mimicking" / metabolic compounds are AICAR (AMPK) and MOTS-c (mitochondrial peptide); mitochondria are also protected by SS-31.
How SLU-PP-332 works — the ERR mechanism
In the research literature, SLU-PP-332 is described as a pan-ERR agonist acting at the level of the nuclear receptor. Below are the three most frequently studied elements.
ERRα AGONISM
Stabilizes the active conformation of ERRα and promotes binding of the coactivator PGC-1α — a key regulator of mitochondria.
MITOCHONDRIAL BIOGENESIS
Activates OXPHOS and β-oxidation programs (↑ TFAM, CPT1, MCAD) → more mitochondria and energy efficiency.
"TRAINING" EFFECT
↑ energy expenditure and fat oxidation, ↓ fat accumulation; ↑ aerobic capacity of muscles (models).
Why the ERR receptor differs from AMPK
ERR agonists act at the level of the nuclear receptor — through coactivation with PGC-1α they reprogram the mitochondrial transcriptome (OXPHOS and β-oxidation genes). This is a profile distinct from AMPK activators (AICAR) or PPAR agonists, but it may be complementary to them in experimental design. The common denominator is "exercise mimetism" — increasing oxidative capacity without training.
In models, improvement in mitochondrial markers was observed in skeletal muscle, liver, adipose tissue and kidneys. This data comes exclusively from preclinical studies and does not constitute a claim about the effect of the research-grade product offered by Peptology.
Pharmacokinetics and pharmacodynamics (research framework)
SLU-PP-332 is a small molecule acting via the nuclear receptor ERR. The most important research characteristics:
- Class: small-molecule pan-ERR agonist (ERRα/β/γ, ERRα preference) — not a peptide
- Targets: the ERRα receptor → coactivation of PGC-1α → OXPHOS / β-oxidation programs
- Cellular effects: ↑ respiratory activity and mitochondrial density in muscle cells
- Effects in models: ↑ endurance, ↑ energy expenditure, ↓ fat mass (DIO / ob-ob mice)
- Status of human data: none — exclusively preclinical models
- Route of administration in protocols: per the research protocol (after reconstitution of the lyophilizate)
Comparison: SLU-PP-332 vs AICAR vs MOTS-c
Within the same category, it is worth comparing SLU-PP-332 with two other "exercise mimetics" — the AMPK activator AICAR and the mitochondrial peptide MOTS-c. All increase oxidative capacity, but via different pathways.
| SLU-PP-332 (this page) | AICAR | MOTS-c | |
|---|---|---|---|
| Compound type | Small molecule (ERR agonist) | Small molecule (AMPK activator) | Mitochondrial peptide (16 aa) |
| Main mechanism | ERRα agonism + PGC-1α (nuclear receptor) | AMPK activation (ZMP) | AMPK activation (its own pathway) |
| Shared effect | Mitochondrial biogenesis, "exercise mimetic" | Aerobic adaptation, "exercise mimetic" | Metabolism, endurance |
| Dose (this version) | 5 mg | 50 mg | 10 / 50 mg |
| Data status | Exclusively preclinical (no human trials) | No phase III; banned substance (WADA) | Limited human data |
SLU-PP-332 acts via the nuclear receptor ERR (with PGC-1α), while AICAR and MOTS-c act via AMPK. The mechanisms are different, but complementary in research on mitochondrial biogenesis. The comparison is indicative in nature and does not constitute a recommendation for use.
Areas of research on SLU-PP-332
SLU-PP-332 is a relatively new research tool from the ERR agonist class. Below are the most frequently explored directions — all exclusively preclinical.
Mitochondrial biogenesis and OXPHOS
The main direction of research on SLU-PP-332 concerns the activation of mitochondrial programs (TFAM, CPT1, MCAD, OXPHOS complexes) via the ERRα–PGC-1α axis — in the muscles, liver, adipose tissue and kidneys of rodents.
Metabolic / anti-obesity profile
In diet-induced obesity and ob-ob models, increased energy expenditure, reduction of fat mass and improvement in glucose tolerance and liver markers were observed. These are observations from animal models.
Research status
SLU-PP-332 is an ERR agonist used in preclinical research. No clinical trials in humans have been conducted — the compound is used exclusively experimentally. This is an early research area, not a confirmed application.
Note: The information is presented for scientific and informational purposes and is based exclusively on the preclinical literature. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.
SLU-PP-332 profile at a glance
- Small-molecule pan-ERR agonist (ERRα preference) — a research tool, not a peptide
- The ERRα–PGC-1α axis → mitochondrial biogenesis, OXPHOS and β-oxidation programs
- "Exercise mimetic" — ↑ aerobic capacity, ↑ energy expenditure (models)
- Anti-obesity profile in metabolic syndrome models (animals)
- Related compounds: AICAR (AMPK), MOTS-c (peptide), SS-31
- Every batch with a CoA and purity ≥ 99%
All information provided refers to the preclinical literature on SLU-PP-332 and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology. There are no clinical trials in humans.
Research dosing protocols
Important: The information below describes schedules used in preclinical research on SLU-PP-332. It is provided for scientific and informational purposes and does not constitute a recommendation for individual use, medical advice or administration instructions. The research-grade SLU-PP-332 offered by Peptology is not a registered drug, and no trials in humans have been conducted.
In research models, SLU-PP-332 is used after reconstitution of the lyophilizate:
- Working reconstitution: 1 mL → 5 mg/mL; calculate precise volumes in the peptide calculator
- As a small molecule, it is also considered in oral formats in animal models
- Schedules are usually spread over time, in the context of metabolic / endurance protocols
- Maximum 3 mL of solvent per vial
In combined designs, SLU-PP-332 is sometimes considered alongside compounds with an AMPK mechanism (AICAR, MOTS-c) as a complementary approach. These schedules come from the research literature and do not constitute a recommendation for self-administration.
Side effects and safety
The safety profile of SLU-PP-332 comes exclusively from animal models — there is no human data. Below are the key observations from research on the molecule.
In models (high exposure)
- Transient changes in liver enzyme activity
- Slight increase in temperature / heart rate
Profile
- Data exclusively from animal models
- Symptoms dependent on dose/exposure
To consider
- No human data whatsoever
- No established safety
- Hypersensitivity to components
In animal models at high exposure, transient changes in liver enzymes and a slight increase in temperature/heart rate were described; analogous symptoms in humans are not known (no studies). This information is scientific in nature and does not constitute an instruction for use.
Storage and reconstitution
SLU-PP-332 is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the solution's lifespan.
- Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
- After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the solution's lifespan relative to standard solvents.
- After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
- Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
- Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
- Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.
Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research compounds. More in the article Bacteriostatic water vs acetic acid vs matrix water.
Frequently asked questions about SLU-PP-332
Is SLU-PP-332 a peptide?
No — it is a small molecule, an agonist of the nuclear ERR receptors (ERRα/β/γ), not a peptide. It is in the Peptology catalog because of its metabolic area, alongside AICAR and MOTS-c.
Is there an approved use in humans?
No — no clinical trials in humans have been conducted. The product is used exclusively for experimental (research) purposes, and all data come from preclinical models.
How does it differ from AMPK activators / PPAR agonists?
ERR agonists act at the level of the nuclear receptor (coactivation with PGC-1α) and reprogram the mitochondrial transcriptome — a profile distinct from AMPK drugs (AICAR) or PPAR, though it may be complementary to them in experiments.
How is SLU-PP-332 stored and reconstituted?
The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.
Where to buy SLU-PP-332 for research?
Peptology offers SLU-PP-332 (5 mg) as a research compound with confirmed purity ≥ 99% and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.
Related products in the Peptology catalog
Researchers working with SLU-PP-332 often also consider other metabolic and mitochondrial compounds. Each of the products below has a certificate of purity (CoA):
AICAR
AMPK activator — another "exercise mimetic"
MOTS-c
Mitochondrial peptide — AMPK, metabolism
5-Amino-1MQ
NNMT inhibitor — NAD⁺, metabolism
SS-31
Mitochondrial peptide — membrane antioxidant
NAD+
Coenzyme of cellular energy
Peptide Matrix Water™
Stabilizing solution for reconstitution
See the full catalog: Peptides for skin, sleep and libido · Peptides for energy and regeneration · Peptides for weight loss · All peptides · Blog on peptide research
Research warning: SLU-PP-332 is offered exclusively for scientific research and in vitro purposes. It is not a medicinal product, is not approved for use in humans or animals, and does not replace medical advice. No clinical trials in humans have been conducted — all data come from preclinical models. All information is provided for scientific and informational purposes; it does not constitute a claim about the effect of the research-grade product offered by Peptology.
Molecule identity
| CAS number | 303760-60-3 |
|---|---|
| Molecular weight | 290.3 g/mol |
| Molecular formula | C18H14N2O2 |
| Class | Synthetic ERRα/β/γ agonist (small molecule) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Laboratory reconstitution
Laboratory protocol — reconstitution, research protocols, storage
Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.
60-second protocol
1. SOLVENT
2. RECONSTITUTION
Add the solvent down the side of the vial, without shaking, wait 10–15 min.
3. CALCULATION
Calculator → concentration mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilized powder |
| Solvent | Peptide Matrix Water |
| Reconstitution volume | 1–3 mL — maximum 3 mL (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration not required) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you need
Precision pipette
Calibrated, 100–1000 µL — for accurately measuring the volume of solvent added to the vial.
70% alcohol swabs
Two swabs — to disinfect the peptide vial and the solvent vial.
Stabilized solvent for lyophilized peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Mistake |
|---|---|
| Disinfect the vial caps and the work surface with 70% alcohol; wear gloves | Working without disinfection |
| Add the solvent slowly along the vial wall | Direct jet onto the powder — foaming and denaturation |
| Gentle rolling between the palms | Shaking — foam, which denatures peptides |
| 10–15 minutes waiting at room temperature | Mechanical mixing or heating |
| Visual check: clear, particle-free | Working with a cloudy or discolored solution |
Calculating concentration
⚠️ Maximum 3 mL solvent. The standard vial does not accommodate larger volumes — do not exceed during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after adding the solvent (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in original packaging. Refrigerator not required.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard any remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade peptide structure.
Four mistakes to avoid
1. Shaking "to dissolve faster"
Foam = denaturation. Only gentle rolling between the palms.
2. Inappropriate solvent
For peptide stability use only sterile, specially formulated solvent — recommended Peptide Matrix Water.
3. Ignoring slight turbidity
Not fully clear = the sample does not meet the criteria for use.
4. Taking it out of the refrigerator "for an hour–two"
Short exposures add up and compromise stability.
Research status: All Peptology products are intended for laboratory and research use only. They are not medicinal products, not approved for human or veterinary use and do not substitute medical advice. The described protocol is standard laboratory practice for working with lyophilized peptides.
Shipping information
🚚 Shipping information
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Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.
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Delivery with GLS to your address in 3–5 working days.
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Shipping costs €5 and is free from €50.
Frequently Asked Questions (FAQ)
Is there an approved use in humans?
No. There are no clinical trials in humans; it is used only for experimental purposes.
How does it differ from PPAR agonists/AMPK activators?
ERR agonists act in a nuclear-receptor manner (coactivation with PGC-1α) and reprogram the mitochondrial transcriptome; the profile is different from PPAR and AMPK agents, but can be complementary in experimental design.
Which tissues are most affected?
Skeletal muscle, liver, adipose tissue and kidney show improvements in mitochondrial and inflammatory markers in rodents.
Where can I buy SLU-PP-332 in Europe and what does it cost?
You can buy SLU-PP-332 in Europe online from Peptology, from 75,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.
Laboratory Analysis
SLU-PP-332 - 5mg - Batch - 0226 - Purity
