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5-Amino-1MQ
5-Amino-1MQ 50 mg – NNMT inhibitor for metabolic and NAD⁺-targeted research
Peptology Ltd. · Peptides for energy and regeneration
5-Amino-1MQ 50 mg – small molecule (5-amino-1-methylquinolinium), selective NNMT inhibitor (nicotinamide N-methyltransferase); research compound for metabolic and NAD⁺-targeted studies. Purity 99%+, HPLC/MS report for every batch. Reconstitution: 1 mL BAC → 50 mg/mL.
📦 The product is in our EU warehouse – delivery within 3–5 working days.
45,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
Last updated: 23/07/2026
What is 5-Amino-1MQ (50 mg)?
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule — a selective inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase). In preclinical models, inhibition of NNMT lowers the level of 1-methylnicotinamide (1-MNA), increases intracellular NAD⁺ and SAM, inhibits lipogenesis and improves metabolic parameters in diet-induced obesity (DIO).
A clarification is worthwhile: 5-Amino-1MQ is not a peptide, but a membrane-permeable small molecule. In the Peptology catalog it is assigned to the category peptides for skin, sleep and libido because of its application area (metabolic optimization); functionally, however, it belongs to the group of metabolic / NAD⁺ compounds — alongside MOTS-c, AICAR and the coenzyme NAD+.
It is a research compound — it is not a medicinal product and holds no authorization for clinical use. It must be emphasized that there are no confirmed RCTs in humans — most data come from cellular and animal models. The product offered by Peptology is a research-grade reagent.
In the version offered by Peptology, 5-Amino-1MQ is available in a 50 mg vial as a lyophilized powder with purity ≥ 99%, confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.
Variant: 5-Amino-1MQ 50 mg
This page concerns one dosage variant — 5-Amino-1MQ 50 mg. Each vial contains 50 mg of the lyophilized compound. A typical working reconstitution is 1 mL → 50 mg/mL; this is a large, "cycle-sized" amount that allows time-spread metabolic protocols or many smaller portions.
VIAL · 50 MG
5-Amino-1MQ (NNMT inhibitor)
50 mg of lyophilized compound, purity ≥ 99% confirmed by CoA for every batch.
REFERENCE CONCENTRATION
50 mg/mL (at 1 mL)
Large dose — calculate volumes precisely in the calculator.
5-Amino-1MQ is offered in the 50 mg variant. Related metabolic compounds are MOTS-c (AMPK/mitochondria) and AOD-9604 (lipolysis); NAD⁺ biology is also addressed by the coenzyme NAD+.
How 5-Amino-1MQ works — the NNMT/NAD⁺ mechanism
In the research literature, 5-Amino-1MQ is described as a selective NNMT inhibitor with metabolic effects. Below are the three most frequently studied elements.
NNMT INHIBITION
Blocks NNMT → ↓ 1-MNA → redirection of nicotinamide into the NAD⁺ salvage pathway.
↑ NAD⁺ / SAM
Increases intracellular NAD⁺ (in cells ~1.2–1.6×) and SAM — support for oxidative metabolism.
↓ LIPOGENESIS
Inhibits lipogenesis and reduces adipocyte mass/size in DIO models; improved glycemic control.
Why NNMT is a research target
NNMT methylates nicotinamide into 1-MNA, "draining" it from the NAD⁺ pathway. By inhibiting NNMT, 5-Amino-1MQ preserves nicotinamide for NAD⁺ storage and at the same time modifies lipid metabolism. This makes it a research tool linking NAD⁺ biology with fat metabolism — a mechanism distinct from the coenzyme NAD+ (which supplies the coenzyme directly).
Importantly, in models 5-Amino-1MQ acts on adipose and muscle tissue without affecting the central nervous system. This data comes from preclinical studies and does not constitute a claim about the effect of the research-grade product offered by Peptology.
Pharmacokinetics and pharmacodynamics (research framework)
5-Amino-1MQ is a small, membrane-permeable molecule with a metabolic profile. The most important research characteristics:
- Class: small molecule (5-amino-1-methylquinolinium), selective NNMT inhibitor — not a peptide
- Targets: the NNMT enzyme in adipose and muscle tissue; the NAD⁺ salvage pathway
- Cellular effects: ↓ 1-MNA, ↑ NAD⁺ (~1.2–1.6×) and SAM, ↓ lipogenesis
- Effects in DIO models: ↓ fat mass, ↓ adipocyte size, better glucose tolerance
- Status of human data: limited — no confirmed RCTs
- Route of administration in protocols: per the research protocol (after reconstitution of the lyophilizate)
Comparison: 5-Amino-1MQ vs MOTS-c vs AOD-9604
Within the same category, it is worth comparing 5-Amino-1MQ with two other metabolic compounds — the mitochondrial peptide MOTS-c and the lipolytic fragment AOD-9604. All concern metabolism and body composition, but via different routes.
| 5-Amino-1MQ (this page) | MOTS-c | AOD-9604 | |
|---|---|---|---|
| Compound type | Small molecule (NNMT inhibitor) | Mitochondrial peptide (16 aa) | hGH fragment 176-191 |
| Main mechanism | NNMT inhibition → ↑ NAD⁺, ↓ lipogenesis | AMPK activation | Lipolysis + antilipogenesis |
| Main research area | Fat metabolism, NAD⁺, liver | Metabolism, endurance | Reduction of adipose tissue |
| Dose (this version) | 50 mg | 10 / 50 mg | 5 mg |
| Best for research on | NAD⁺ biology + fat metabolism | Mitochondria and AMPK | Targeted lipolysis |
5-Amino-1MQ acts through NNMT inhibition (raising NAD⁺ and limiting lipogenesis), MOTS-c through AMPK, and AOD-9604 through direct lipolysis. The comparison is indicative in nature and does not constitute a recommendation for use.
Areas of research on 5-Amino-1MQ
5-Amino-1MQ is a research tool for NNMT inhibition, mainly in preclinical models. Below are the most frequently explored directions — with a strong caveat about the absence of human data.
Fat metabolism and obesity (DIO)
In diet-induced obesity models (mice) and in adipocytes, 5-Amino-1MQ was associated with inhibition of lipogenesis, reduction of fat mass and adipocyte size, and improvement in glucose tolerance and insulin sensitivity.
NAD⁺ and SAM biology
In cells, 5-Amino-1MQ increases the level of NAD⁺ (concentration-dependent, ~1.2–1.6×) and SAM — which makes it relevant in research on mitochondrial function and energy homeostasis. This complements direct supplementation with the coenzyme NAD+.
New directions: muscle, liver
Studies are emerging on muscle function in aging, liver pathology and onco-/immunomodulatory contexts (NNMT in the tumor microenvironment). These are early research areas, not confirmed applications. There are no confirmed RCTs in humans.
Note: The information is presented for scientific and informational purposes and is based mainly on the preclinical literature. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.
5-Amino-1MQ profile at a glance
- Selective NNMT inhibitor (small molecule) — a metabolism research tool, not a peptide
- Raises NAD⁺ and SAM — by redirecting nicotinamide into the NAD⁺ salvage pathway
- Inhibits lipogenesis — reduction of fat mass in DIO models
- Acts peripherally (adipose tissue, muscles) without affecting the CNS
- Related compounds: MOTS-c (AMPK), AOD-9604 (lipolysis), NAD+ (coenzyme)
- Every batch with a CoA and purity ≥ 99%
All information provided refers to the research literature on 5-Amino-1MQ and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology. There are no confirmed RCTs in humans.
Research dosing protocols
Important: The information below describes schedules used in research on 5-Amino-1MQ. It is provided for scientific and informational purposes and does not constitute a recommendation for individual use, medical advice or administration instructions. The research-grade 5-Amino-1MQ offered by Peptology is not a registered drug.
In research protocols, 5-Amino-1MQ is used after reconstitution of the lyophilizate:
- Working reconstitution: 1 mL → 50 mg/mL; calculate precise volumes in the peptide calculator
- As a small molecule, it is also considered in oral formats in research models
- Schedules are usually spread over time, in the context of metabolic / NAD⁺ protocols
- The large 50 mg vial allows many smaller portions or longer series (max. 3 mL of solvent)
In combined designs, 5-Amino-1MQ is sometimes paired with NAD⁺ precursors / mitochondrial markers and other metabolic compounds, such as MOTS-c or AICAR. These schedules come from the research literature and do not constitute a recommendation for self-administration.
Side effects and safety
Published human data are scarce. Materials and reviews mention mild, transient symptoms. Long-term safety in humans has not been established.
Mentioned (mild)
- Nausea
- Fatigue
- Dizziness
Profile (models)
- Peripheral action (no CNS)
- Good tolerability in animal models
- Selectivity toward NNMT
To consider
- No established safety in humans
- No confirmed RCTs
- Hypersensitivity to components
Reported symptoms are mild and transient, but long-term safety in humans has not been established (no completed, published late-phase studies). This information is scientific in nature and does not constitute an instruction for use.
Storage and reconstitution
5-Amino-1MQ is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the solution's lifespan.
- Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
- After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the solution's lifespan relative to standard solvents.
- After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
- Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
- Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
- Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.
Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research compounds. More in the article Bacteriostatic water vs acetic acid vs matrix water.
Frequently asked questions about 5-Amino-1MQ
Is 5-Amino-1MQ a peptide?
No — it is a small molecule (5-amino-1-methylquinolinium), a selective inhibitor of the enzyme NNMT, not a peptide. It is in the Peptology catalog because of its metabolic application area, alongside compounds such as MOTS-c and AICAR.
What does NNMT do and why inhibit it?
NNMT methylates nicotinamide into 1-MNA. Its inhibition preserves nicotinamide for NAD⁺ storage and modifies lipid metabolism — hence the interest in 5-Amino-1MQ in metabolic research.
Does it increase NAD⁺ levels?
In cells, 5-Amino-1MQ produces a concentration-dependent increase in NAD⁺ (~1.2–1.6×). This complements direct supplementation with the coenzyme NAD+, but acts by a different mechanism (enzyme inhibition).
Is there evidence of adipose tissue reduction?
Yes — in DIO mice and in adipocytes: ↓ lipogenesis, ↓ fat mass/adipocyte size, better glycemic control. However, confirmed RCTs in humans are still lacking.
How is 5-Amino-1MQ stored and reconstituted?
The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.
Where to buy 5-Amino-1MQ for research?
Peptology offers 5-Amino-1MQ (50 mg) as a research compound with confirmed purity ≥ 99% and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.
Related products in the Peptology catalog
Researchers working with 5-Amino-1MQ often also consider related metabolic and NAD⁺ compounds. Each of the products below has a certificate of purity (CoA):
MOTS-c
Mitochondrial peptide — AMPK, metabolism
AICAR
AMPK activator — metabolic control
NAD+
Coenzyme of cellular energy (direct)
AOD-9604
Lipolytic hGH fragment (176-191)
SS-31
Mitochondrial peptide — membrane antioxidant
Peptide Matrix Water™
Stabilizing solution for reconstitution
See the full catalog: Peptides for skin, sleep and libido · Peptides for energy and regeneration · Peptides for weight loss · All peptides · Blog on peptide research
Research warning: 5-Amino-1MQ is offered exclusively for scientific research and in vitro purposes. It is not a medicinal product, is not approved for use in humans or animals, and does not replace medical advice. There are no confirmed RCTs in humans, and long-term safety has not been established. All information comes from the research literature and is provided for scientific and informational purposes; it does not constitute a claim about the effect of the research-grade product offered by Peptology.
Laboratory reconstitution
Laboratory protocol — reconstitution, research protocols, storage
Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.
60-second protocol
1. SOLVENT
2. RECONSTITUTION
Add the solvent down the side of the vial, without shaking, wait 10–15 min.
3. CALCULATION
Calculator → concentration mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilized powder |
| Solvent | Peptide Matrix Water |
| Reconstitution volume | 1–3 mL — maximum 3 mL (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration not required) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you need
Precision pipette
Calibrated, 100–1000 µL — for accurately measuring the volume of solvent added to the vial.
70% alcohol swabs
Two swabs — to disinfect the peptide vial and the solvent vial.
Stabilized solvent for lyophilized peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Mistake |
|---|---|
| Disinfect the vial caps and the work surface with 70% alcohol; wear gloves | Working without disinfection |
| Add the solvent slowly along the vial wall | Direct jet onto the powder — foaming and denaturation |
| Gentle rolling between the palms | Shaking — foam, which denatures peptides |
| 10–15 minutes waiting at room temperature | Mechanical mixing or heating |
| Visual check: clear, particle-free | Working with a cloudy or discolored solution |
Calculating concentration
⚠️ Maximum 3 mL solvent. The standard vial does not accommodate larger volumes — do not exceed during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after adding the solvent (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 50 mg | 50 mg/mL | 25 mg/mL | 16.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in original packaging. Refrigerator not required.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard any remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade peptide structure.
Four mistakes to avoid
1. Shaking "to dissolve faster"
Foam = denaturation. Only gentle rolling between the palms.
2. Inappropriate solvent
For peptide stability use only sterile, specially formulated solvent — recommended Peptide Matrix Water.
3. Ignoring slight turbidity
Not fully clear = the sample does not meet the criteria for use.
4. Taking it out of the refrigerator "for an hour–two"
Short exposures add up and compromise stability.
Research status: All Peptology products are intended for laboratory and research use only. They are not medicinal products, not approved for human or veterinary use and do not substitute medical advice. The described protocol is standard laboratory practice for working with lyophilized peptides.
Shipping information
🚚 Shipping information
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Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.
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Delivery with GLS to your address in 3–5 working days.
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Shipping costs €5 and is free from €50.
Frequently Asked Questions (FAQ)
What does NNMT do and why is it a target?
NNMT methylates nicotinamide → 1-MNA. Its inhibition preserves nicotinamide for NAD⁺ salvage and modifies lipid metabolism.
Does it increase NAD⁺?
In cells 5-Amino-1MQ leads to concentration-dependent ↑NAD⁺ (~1.2–1.6×).
In what form is 5-Amino-1MQ supplied and how should it be stored?
It is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store the unopened vial dry and protected from light, ideally at 2–8 °C. After laboratory reconstitution, keep the solution at 2–8 °C and use it within the period stated in the “Laboratory reconstitution” tab (up to 60 days with Peptide Matrix Water).
Where can I buy 5-Amino-1MQ in Europe and what does it cost?
You can buy 5-Amino-1MQ in Europe online from Peptology, from 45,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.
Laboratory Analysis
5-Amino-1MQ - 50 mg - Batch - 0226 - Purity
