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Kisspeptin-10
Kisspeptin-10 5 mg/10 mg – Peptide regulator of the hormonal axis (GnRH stimulator)
Peptology Ltd. · Peptides for immunity and hormonal balance
Kisspeptin-10 5 mg – the C-terminal decapeptide fragment of kisspeptin (YNWNSFGLRF-NH₂), a KISS1R (GPR54) receptor agonist; research peptide for studies of the HPG axis and GnRH regulation. Purity 99%+, HPLC/MS report for every batch.
📦 The product is in our EU warehouse – delivery within 3–5 working days.
30,00 € · In stock
- 5mg — 30,00 €
- 10mg — 49,00 €
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 / 0126 |
Last updated: 18/10/2026
What is Kisspeptin-10 5 mg / 10 mg?
Kisspeptin-10 is a synthetic, active fragment of natural kisspeptin — a peptide playing a key "trigger" role in the reproductive axis. It acts "at the very top" of the hypothalamic-pituitary-gonadal (HPG) axis: it stimulates the hypothalamus to secrete GnRH, which in turn triggers the release of LH and FSH, and further the production of testosterone/estrogens.
Kisspeptin-10 belongs to the category peptides for immunity and hormonal balance. In the HPG axis it acts "one level higher" than Gonadorelin (which is itself GnRH acting on the pituitary) and much higher than HCG (which mimics LH itself).
It is a research compound — it is not a medicinal product and holds no authorization for clinical use. The product offered by Peptology is a research-grade reagent, not intended for the diagnosis or treatment of fertility or hormonal disorders.
Kisspeptin-10 is available in two dosage variants — 5 mg and 10 mg — as a lyophilized peptide of high purity, confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.
How Kisspeptin-10 works — the top of the HPG axis
In the research literature, Kisspeptin-10 is described as the master regulator of GnRH secretion. Below are the three most frequently studied elements.
GnRH STIMULATION
Activates GnRH neurons in the hypothalamus → GnRH secretion → the LH/FSH cascade.
LH / FSH → GONADS
LH and FSH stimulate the gonads → endogenous testosterone/estrogen, ovulation, spermatogenesis.
LIBIDO / MOOD
In studies associated with an effect on libido and sexual behavior (through the HPG axis and brain centers).
Why the "highest level" of the axis matters
Kisspeptin is the natural "switch" of the reproductive axis — it is what initiates GnRH secretion. Acting so high up, Kisspeptin-10 works with the body's natural rhythm and feedback mechanisms, in contrast to Gonadorelin (which delivers a ready GnRH signal to the pituitary) or HCG (which bypasses both levels, mimicking LH directly at the gonads).
In studies, Kisspeptin-10 is considered, among other things, in the context of hypogonadism, functional amenorrhea and restoring the axis after its suppression (PCT). This data comes from the literature and does not constitute a claim about the effect of the research-grade product offered by Peptology.
Pharmacokinetics and pharmacodynamics (research framework)
Kisspeptin-10 is a short peptide with a fast but transient effect on the HPG axis. The most important research characteristics:
- Class: active fragment of kisspeptin (peptide), agonist of the KISS1R/GPR54 receptor
- Target: GnRH neurons in the hypothalamus → GnRH secretion → LH/FSH
- Position in the HPG axis: the highest — the "trigger" of the entire reproductive cascade
- Effect: increase in LH and FSH; indirectly testosterone/estrogens
- Short duration of action: Kisspeptin-10 has a short t½ — pulsatile/repeated schedules are often considered
- Route of administration in protocols: subcutaneous, per the research protocol
Variant comparison: Kisspeptin-10 5 mg vs 10 mg
Kisspeptin-10 is available in two doses. Both variants are the same peptide — the difference concerns only the amount of substance in the vial, which translates into the scale and length of the research protocol.
| Kisspeptin-10 5 mg | Kisspeptin-10 10 mg | |
|---|---|---|
| Amount of peptide | 5 mg | 10 mg |
| Peptide | Kisspeptin-10 | Kisspeptin-10 |
| Purity | High (CoA per batch) | High (CoA per batch) |
| Protocol scale | Smaller / shorter | Larger / longer |
| Best for | Initial / shorter research series | Extended protocols / economy of scale |
Both variants are the same high-purity peptide — the difference concerns only the amount in the vial. The choice depends on the scale of the planned protocol. Regardless of the variant, it is worth adding Peptide Matrix Water™ for reconstitution.
Comparison: Kisspeptin-10 vs Gonadorelin vs HCG
Three compounds from the same category act on the HPG axis at different levels. Kisspeptin-10 is "highest" (stimulates GnRH), Gonadorelin acts on the pituitary (GnRH → LH/FSH), and HCG is "lowest" (mimics LH).
| Kisspeptin-10 (this page) | Gonadorelin | HCG | |
|---|---|---|---|
| Level in the HPG axis | Hypothalamus (↑ GnRH) — highest | Pituitary (GnRH → LH/FSH) | Gonads (mimics LH) |
| What it stimulates | Secretion of the body's own GnRH | LH + FSH (directly the pituitary) | Directly the LH receptor |
| Compatibility with the natural rhythm | Highest (works with the axis) | High (dependent on pulsatile mode) | Bypasses the pituitary |
| Dose (variants) | 5 / 10 mg | 2 mg | 5000 IU |
| Best for research on | GnRH regulation, fertility, libido | Pituitary function, PCT | LH-type support |
Three levels of the same axis: Kisspeptin-10 stimulates GnRH secretion (highest, works with the natural rhythm), Gonadorelin delivers a GnRH signal to the pituitary, and HCG mimics LH itself. The comparison is indicative in nature and does not constitute a recommendation for use.
Areas of research on Kisspeptin-10
Kisspeptin is one of the most important discoveries in the neuroendocrinology of reproduction. Below are the most frequently explored research directions.
Fertility and reproductive functions
In studies, Kisspeptin-10 raised LH and FSH in men with hypogonadism and was associated with increased ovulation and fertility in women with functional amenorrhea — acting "at the source" of the HPG axis.
Libido, mood and sexual behavior
In controlled studies, kisspeptin was associated with improved mood and sexual behavior — through its effect on the HPG axis and brain centers related to arousal. These are research directions, not confirmed applications.
Restoring the axis (PCT)
Kisspeptin-10 is considered in protocols for restoring the HPG axis after its suppression (e.g. after androgen therapy) and is sometimes paired with HCG or Gonadorelin. These are research directions, not confirmed applications of the research-grade product.
Note: The information is presented for scientific and informational purposes and is based on the literature on kisspeptin and the HPG axis. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.
Kisspeptin-10 profile at a glance
- Active fragment of kisspeptin — the natural "trigger" of the reproductive axis (KISS1R/GPR54)
- Stimulates GnRH secretion → LH/FSH → testosterone/estrogens (acts "at the source")
- Works with the natural rhythm of the axis — unlike HCG (which bypasses the pituitary)
- Studied for fertility, hypogonadism, amenorrhea, libido
- HPG axis: higher than Gonadorelin and HCG
- Every batch with a CoA and confirmed laboratory purity
All information provided refers to the research literature on Kisspeptin-10 and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology.
Research dosing protocols
Important: The information below describes schedules used in research on Kisspeptin-10. It is provided for scientific and informational purposes and does not constitute a recommendation for individual use, medical advice or administration instructions. The research-grade Kisspeptin-10 offered by Peptology is not a registered drug.
In research protocols, Kisspeptin-10 is usually administered after reconstitution of the lyophilizate, most often subcutaneously:
- Due to the short duration of action, pulsatile or repeated schedules are often considered
- The 5 mg variant for initial, shorter series; 10 mg for extended protocols
- Calculate precise volumes and units in the peptide calculator (max. 3 mL of solvent per vial)
- In hormonal protocols it is sometimes considered together with HCG or Gonadorelin
These schedules come from the research literature and do not constitute a recommendation for self-administration.
Side effects and safety
In research observations, Kisspeptin-10 is associated with a very low risk of side effects, especially with controlled dosing. The data concern research on the molecule.
Rare (mild)
- Mild headache or mood swings
- Transient facial redness
Tolerability profile
- Very low risk with controlled dosing
- Works with the natural rhythm of the axis
- Suitable for men and women (studies)
To consider
- Increased libido (especially in men)
- Caution in hormonal/reproductive disorders
- Hypersensitivity to components
Most reported effects are mild and transient, and the risk profile is low with controlled dosing. This information is scientific in nature and does not constitute an instruction for use.
Storage and reconstitution
Kisspeptin-10 is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.
- Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
- After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
- After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
- Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
- Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
- Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.
Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.
Frequently asked questions about Kisspeptin-10
What exactly is Kisspeptin-10?
It is an active fragment of natural kisspeptin — a peptide that initiates the reproductive axis. It stimulates GnRH neurons in the hypothalamus, which triggers the LH/FSH cascade and indirectly the production of sex hormones. The results come from the research literature.
How does it differ from Gonadorelin and HCG?
These are three levels of the HPG axis. Kisspeptin-10 acts highest (stimulates GnRH secretion, works with the natural rhythm), Gonadorelin is itself GnRH acting on the pituitary, and HCG mimics LH, bypassing the pituitary.
Is it suitable for PCT?
In the research literature, Kisspeptin-10 is considered in protocols for restoring the HPG axis after its suppression, because it supports the natural production of LH and FSH. This is a research context, not a recommendation for use.
Can it be used in women?
In studies, Kisspeptin-10 was analyzed in both men and women (including in models of anovulation and functional amenorrhea). This is research data, not clinical recommendations.
How is Kisspeptin-10 stored and reconstituted?
The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.
Where to buy Kisspeptin-10 for research?
Peptology offers Kisspeptin-10 (5 mg / 10 mg) as a research peptide with confirmed purity and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.
Related products in the Peptology catalog
Researchers working with Kisspeptin-10 often also consider related peptides of the hormonal axis and immunity. Each of the products below has a certificate of purity (CoA):
Gonadorelin
GnRH agonist — the pituitary level of the HPG axis
HCG 5000 IU
Mimics LH — the gonadal level of the HPG axis
Thymosin Alpha-1
Immunoneuroendocrine regulation
Semax
Neuropeptide — neuroendocrine adaptation
Thymulin
Neuroimmune modulator
Peptide Matrix Water™
Stabilizing solution for reconstitution
See the full catalog: Peptides for immunity and hormonal balance · Peptides for skin, sleep and libido · Recovery and anabolic peptides · All peptides · Blog on peptide research
Research warning: Kisspeptin-10 is offered exclusively for scientific research and in vitro purposes. It is not a medicinal product, is not approved for use in humans or animals, and does not replace medical advice. It is not intended for the diagnosis or treatment of fertility or hormonal disorders. All information comes from the research literature and is provided for scientific and informational purposes; it does not constitute a claim about the effect of the research-grade product offered by Peptology.
Molecule identity
| CAS number | 374675-21-5 |
|---|---|
| Molecular weight | 1302.4 g/mol |
| Molecular formula | C63H83N17O14 |
| Class | Decapeptide, KISS1R agonist (GPR54) |
| Form | Lyophilised powder in a glass vial |
| Storage | Lyophilisate: 2–8 °C, dry and protected from light · after reconstitution: 2–8 °C |
Laboratory reconstitution
Laboratory protocol — reconstitution, research protocols, storage
Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.
60-second protocol
1. SOLVENT
2. RECONSTITUTION
Add the solvent down the side of the vial, without shaking, wait 10–15 min.
3. CALCULATION
Calculator → concentration mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilized powder |
| Solvent | Peptide Matrix Water |
| Reconstitution volume | 1–3 mL — maximum 3 mL (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration not required) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you need
Precision pipette
Calibrated, 100–1000 µL — for accurately measuring the volume of solvent added to the vial.
70% alcohol swabs
Two swabs — to disinfect the peptide vial and the solvent vial.
Stabilized solvent for lyophilized peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Mistake |
|---|---|
| Disinfect the vial caps and the work surface with 70% alcohol; wear gloves | Working without disinfection |
| Add the solvent slowly along the vial wall | Direct jet onto the powder — foaming and denaturation |
| Gentle rolling between the palms | Shaking — foam, which denatures peptides |
| 10–15 minutes waiting at room temperature | Mechanical mixing or heating |
| Visual check: clear, particle-free | Working with a cloudy or discolored solution |
Calculating concentration
⚠️ Maximum 3 mL solvent. The standard vial does not accommodate larger volumes — do not exceed during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after adding the solvent (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 5 mg | 5 mg/mL | 2.5 mg/mL | 1.67 mg/mL |
| 10 mg | 10 mg/mL | 5 mg/mL | 3.33 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in original packaging. Refrigerator not required.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard any remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade peptide structure.
Four mistakes to avoid
1. Shaking "to dissolve faster"
Foam = denaturation. Only gentle rolling between the palms.
2. Inappropriate solvent
For peptide stability use only sterile, specially formulated solvent — recommended Peptide Matrix Water.
3. Ignoring slight turbidity
Not fully clear = the sample does not meet the criteria for use.
4. Taking it out of the refrigerator "for an hour–two"
Short exposures add up and compromise stability.
Research status: All Peptology products are intended for laboratory and research use only. They are not medicinal products, not approved for human or veterinary use and do not substitute medical advice. The described protocol is standard laboratory practice for working with lyophilized peptides.
Shipping information
🚚 Shipping information
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Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.
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Delivery with GLS to your address in 3–5 working days.
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Shipping costs €5 and is free from €50.
Frequently Asked Questions (FAQ)
Will it increase testosterone?
Indirectly – by increasing LH, which stimulates natural testosterone production.
In what form is Kisspeptin-10 supplied and how should it be stored?
It is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store the unopened vial dry and protected from light, ideally at 2–8 °C. After laboratory reconstitution, keep the solution at 2–8 °C and use it within the period stated in the “Laboratory reconstitution” tab (up to 60 days with Peptide Matrix Water).
What purity does Kisspeptin-10 have and how is it tested?
Every batch has a purity of 99% or higher, confirmed by HPLC and mass spectrometry (MS) and documented in a certificate of analysis (CoA). The report for the current batch is shown in the “Laboratory Analysis” tab.
Where can I buy Kisspeptin-10 in Europe and what does it cost?
You can buy Kisspeptin-10 in Europe online from Peptology, from 30,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.
Laboratory Analysis
Kisspeptin-10 - 5 mg - Batch - 0126 - Purity
Kisspeptin-10 - 10mg - Batch - 0226 - Purity
