GHRP-2 10 mg – Ghrelin mimetic (GHS-R1a agonist)

What is GHRP-2 (10 mg)?

GHRP-2 (growth hormone-releasing peptide 2) is a synthetic ghrelin mimetic — a GHS-R1a receptor agonist, which induces the pulsatile release of growth hormone (GH) from the pituitary. It acts via a GHRH-independent pathway and retains activity even when the GHRH pathway is blocked — which is why, in combination with GHRH analogs (like CJC-1295 or Sermorelin), it shows an additive/synergistic effect on GH peaks.

GHRP-2 belongs to the group of GH secretagogues (GHS) — the "classic" GHRPs, alongside GHRP-6 and Hexarelin. In the Peptology catalog it is assigned to the category peptides for skin, sleep and libido (GH axis and regeneration segment).

It is a research compound — it is not a medicinal product and holds no authorization for clinical use. In human studies, GHRP-2 produces marked GH spikes, but as an "older" GHRP it can also raise the level of prolactin (PRL), ACTH and cortisol (a class effect). The product offered by Peptology is a research-grade reagent.

In the version offered by Peptology, GHRP-2 is available in a 10 mg vial as a lyophilized peptide with purity ≥ 99%, confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.

Variant: GHRP-2 10 mg

This page concerns one dosage variant — GHRP-2 10 mg. Each vial contains 10 mg of the lyophilized peptide. A typical working reconstitution is 1 mL → 10 mg/mL, and the research doses described in the literature usually fall in the range of 100–300 µg.

GHRP-2 is offered in the 10 mg variant. If you are interested in a GHS with a stronger effect on appetite, check GHRP-6, and for a selective variant (less effect on cortisol/PRL) — Ipamorelin.

How GHRP-2 works — the GHS-R1a mechanism

In the research literature, GHRP-2 is described as a potent GH secretagogue acting via the ghrelin receptor. Below are the three most frequently studied elements.

Why synergy with GHRH matters

GH is released via two independent pathways: GHRH (analogs like CJC-1295 / Sermorelin) and the ghrelin pathway (GHS-R1a — GHRP-2). Simultaneous stimulation of both gives additive GH secretion, greater than each pathway alone. That is why, in research protocols, GHRP-2 is sometimes combined with GHRH analogs.

GHRP-2 has a short half-life (a GH peak window on the order of minutes–hours), unlike long-acting non-peptide GHS. This data comes from studies and does not constitute a claim about the effect of the research-grade product offered by Peptology.

Pharmacokinetics and pharmacodynamics (research framework)

GHRP-2 is a short-acting GH secretagogue from the ghrelin mimetic group. The most important research characteristics:

• Class: synthetic GHRP, ghrelin receptor GHS-R1a agonist
• Target: GHS-R1a in the hypothalamic-pituitary axis (GHRH-independent pathway)
• Half-life: short — GH peaks in a window of minutes–hours
• Synergy: additive GH secretion when combined with GHRH (CJC-1295/Sermorelin)
• Class effects: increased appetite; possible increase in PRL/ACTH/cortisol
• Reference concentration: 10 mg in 1 mL = 10 mg/mL; research doses usually 100–300 µg

Comparison: GHRP-2 vs GHRP-6 vs Ipamorelin

All three are GH secretagogues (GHS-R1a agonists), but they differ in the strength of their effect on appetite and their hormonal profile (PRL/ACTH/cortisol). GHRP-2's closest "cousin" is GHRP-6; for contrast, the selective Ipamorelin is added.

GHRP-2 and GHRP-6 are close "cousins" — both strongly stimulate GH and have class effects (PRL/ACTH/cortisol), but GHRP-6 stands out for the strongest appetite stimulation. Ipamorelin is a newer, selective alternative with minimal effect on cortisol/PRL and appetite. The comparison is indicative in nature and does not constitute a recommendation for use.

Areas of research on GHRP-2

GHRP-2 is a well-described GH secretagogue, often used as a "comparison platform" for other GHS. Below are the most frequently explored directions.

GH stimulation and synergy with GHRH

In human studies, GHRP-2 produces strong GH spikes, and simultaneous administration with GHRH gives an additive effect (greater than each alone). This is the main reason why, in research protocols, GHRP-2 is combined with GHRH analogs, like CJC-1295.

Appetite and hormonal profile

Like other ghrelin mimetics, GHRP-2 increases appetite. As an "older" GHRP it can also raise PRL, ACTH and cortisol — this is a class effect, less pronounced than with GHRP-6 in the context of appetite, but present.

Long-term data

There is a limited number of long-term RCTs for peptide GHS, although the field is well described in review papers. This is a research area, not a confirmed therapeutic application of the research-grade product.

Note: The information is presented for scientific and informational purposes and is based on the literature on GH secretagogues. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.

GHRP-2 profile at a glance

• Potent GH secretagogue (ghrelin mimetic) — pulsatile GH release via GHS-R1a
• GHRH-independent pathway — additive GH secretion when combined with GHRH analogs
• Short half-life — good for controlled, short GH peaks
• Class effects: increased appetite, possible increase in PRL/ACTH/cortisol
• Closest "cousin": GHRP-6; selective alternative: Ipamorelin
• Every batch with a CoA and purity ≥ 99%

All information provided refers to the research literature on GHRP-2 and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology.

Research dosing protocols

In research protocols, GHRP-2 is usually administered after reconstitution of the lyophilizate, most often subcutaneously:

• Working reconstitution: 1 mL → 10 mg/mL; the described research doses are usually 100–300 µg
• Often administered in "pulses" (e.g. before sleep or around training), away from carbohydrate meals
• Recommended titration and breaks in cycles to avoid tachyphylaxis (weakening of the response)
• Often combined with GHRH analogs (CJC-1295 / Sermorelin) for an additive effect — calculate in the peptide calculator

A ready-made GHRH + GHS complex is available as CJC-1295 + Ipamorelin. These schedules come from the research literature and do not constitute a recommendation for self-administration.

Side effects and safety

In research observations, GHRP-2 is described as well tolerated, but as an "older" GHRP it has class effects. Side effects are usually mild and transient. The data concern research on the molecule.

Good research practice is to titrate doses and maintain breaks in cycles to limit tachyphylaxis and class effects. If a "clean" GH profile is key, the selective alternative is Ipamorelin. This information is scientific in nature and does not constitute an instruction for use.

Storage and reconstitution

GHRP-2 is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.

• Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
• After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
• After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
• Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
• Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
• Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.

Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.

Frequently asked questions about GHRP-2

How does GHRP-2 differ from GHRP-6?

Both are "classic" GHRPs with a strong effect on GH and similar class effects (PRL/ACTH/cortisol). The most important difference: GHRP-6 very strongly stimulates appetite (that is its hallmark), whereas GHRP-2 gives a moderate–significant appetite with a strong GH pulse.

And how does it differ from Ipamorelin?

Ipamorelin is a newer, more selective GH secretagogue — it gives a "cleaner" GH pulse with minimal effect on cortisol, PRL and appetite. GHRP-2 is stronger but less selective.

Is there synergy with GHRH?

Yes — simultaneous administration of GHRP-2 with a GHRH analog (CJC-1295 / Sermorelin) gives additive GH secretion, greater than each pathway alone.

How long does GHRP-2 act?

GHRP-2 has a short half-life — a GH peak window on the order of minutes to an hour, unlike long-acting non-peptide GHS. That is why it is administered in "pulses".

How is GHRP-2 stored and reconstituted?

The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.

Where to buy GHRP-2 for research?

Peptology offers GHRP-2 (10 mg) as a research peptide with confirmed purity ≥ 99% and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.

Related products in the Peptology catalog

Researchers working with GHRP-2 often also consider other GH secretagogues and GHRH analogs for combined schedules. Each of the products below has a certificate of purity (CoA):

See the full catalog: Peptides for skin, sleep and libido · Recovery and anabolic peptides · Peptides for energy and regeneration · All peptides · Blog on peptide research

Molecule identity

Laboratory reconstitution

Laboratory protocol — reconstitution, research protocols, storage

Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.

60-second protocol

Quick reference

What you need

Five rules for reconstitution

Calculating concentration

Storage

Four mistakes to avoid

Shipping information

🚚 Shipping information

• Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.

• Delivery with GLS to your address in 3–5 working days.

• Shipping costs €5 and is free from €50.

Frequently Asked Questions (FAQ)

How does GHRP-2 differ from GHRP-6/Ipamorelin?

GHRP-2 and GHRP-6 are more „classical“ GHS and in humans have been associated with PRL/ACTH/cortisol responses; Ipamorelin has a more selective GH profile with a weaker effect on cortisol/PRL.

Is there synergy with GHRH?

Yes. Co-administration of GHRP-2 with GHRH demonstrates additive GH secretion compared with administration alone.

How long does the effect last?

GHRP-2 is short-acting (a minute-to-hour window for the GH peak), unlike non-peptide GHS such as MK-0677.

Where can I buy GHRP-2 in Europe and what does it cost?

You can buy GHRP-2 in Europe online from Peptology, from 40,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.

Laboratory Analysis

GHRP-2 - 10mg - Batch - 0226 - Purity