Hexarelin 5 mg – GH secretagogue (GHS-R1a agonist) for research

What is Hexarelin (5 mg)?

Hexarelin is a synthetic hexapeptide of the GHRP group (growth-hormone-releasing peptides) and a ghrelin receptor agonist (GHS-R1a). It is a structural analog of GHRP-6, but with greater stability and higher receptor affinity — in the literature described as the most potent synthetic GH secretagogue, triggering the release of growth hormone at doses up to 10 times lower than GHRP-6.

Two features distinguish Hexarelin. First — potency: it binds GHS-R1a more strongly than ghrelin itself and produces the strongest GH pulses among the classic GHRPs, additionally inhibiting somatostatin (the hormone that blocks GH). Second — cardioprotective action via the CD36 receptor, which in studies is described as independent of growth hormone (observed even in GH-deficient models). This distinguishes Hexarelin from the other secretagogues.

Hexarelin acts on the GHS-R1a receptor — the same one as Ipamorelin or GHRP-2, but distinct from the GHRH receptor targeted by analogs like CJC-1295. Because these are two independent pathways, combining Hexarelin with a GHRH analog gives a strong synergistic effect in studies.

Hexarelin is studied in the context of the GH/IGF-1 axis, hypertrophy, regeneration and cardiovascular function. It is a research peptide — it holds no authorization as a medicinal product. It belongs to the category recovery and anabolic peptides.

In the version offered by Peptology, Hexarelin is supplied as a lyophilized peptide with purity above 99% (HPLC/MS), confirmed by independent laboratory analysis (CoA for every batch), in a 5 mg vial size. The product is intended exclusively for scientific research and in vitro applications.

Available vial size: 5 mg

Hexarelin is available in a 5 mg lyophilized format that covers typical research scales — from single in vitro series to longer GH-axis protocols, including schedules combined with a GHRH analog.

The 5 mg vial size has purity > 99% and a laboratory certificate for the batch. Due to Hexarelin's high potency, precise dose calculation is important.

How Hexarelin works — the most potent GH secretagogue

In the research literature, Hexarelin is described as a molecule with three characteristic features — exceptional potency, cardiac action and a tendency toward receptor desensitization. These three elements together define its profile.

Why potency and cardioprotection matter

Hexarelin is the most potent of the classic GHRPs — it produces larger GH pulses than GHRP-2 or GHRP-6 at the same molar dose. Additionally, its action via the CD36 receptor makes it unique in this class: in research models its cardioprotective effect was observed even under GH deficiency, indicating a mechanism independent of the growth axis.

The flip side of high potency is faster desensitization of the GHS-R1a receptor, which is why Hexarelin is used in shorter cycles than other GHRPs. In research schedules it is combined with a GHRH analog (e.g. CJC-1295) acting on a separate receptor. This data comes from pharmacological studies and does not constitute a claim about the effect of the research-grade product.

Pharmacokinetics and pharmacodynamics of Hexarelin

Hexarelin is a metabolically stable hexapeptide, described in the published data as a fast-acting secretagogue with a short profile, triggering a strong GH pulse soon after administration.

• GH peak: about 30 minutes after administration — one of the fastest-acting secretagogues
• Half-life: short, on the order of about 55 minutes (approximate figures from the literature)
• Targets: the ghrelin receptor GHS-R1a (pituitary) and the CD36 receptor (cardiac tissue)
• Potency: GH-releasing activity at doses ~10× lower than GHRP-6
• Somatostatin inhibition: additionally increases pulsatile GH release
• Research schedule: subcutaneous administration, in short cycles (e.g. 4–6 weeks) with breaks

Hexarelin vs Ipamorelin vs GHRP-6

The table below compares three GHRP secretagogues acting on the same GHS-R1a receptor, but differing in potency, selectivity and side-effect profile. Hexarelin is the most potent, Ipamorelin the cleanest, and GHRP-6 stands out for strong appetite stimulation. The data are scientific and comparative in nature.

The values are approximate and come from the pharmacological literature on GH secretagogues. The table is scientific and comparative in nature and does not constitute a direct head-to-head comparison or a claim about the effect of the research-grade product.

Research and clinical data on Hexarelin

Hexarelin is one of the best-studied GH secretagogues and an object of particular interest because of its cardiac action. Below are the most important observations from the literature.

Strong growth hormone release

In studies, Hexarelin produced a marked increase in plasma GH concentrations soon after administration — stronger than other classic GHRPs at an equivalent dose. This profile makes it a tool for research on peak GH pulses and the GH/IGF-1 axis.

Cardioprotection via CD36

A distinguishing feature of Hexarelin is its cardioprotective action, associated with the CD36 receptor and the regulation of calcium handling in cardiomyocytes, as well as protection from ischemia-reperfusion injury. In research models these effects were observed even under GH deficiency, indicating a mechanism independent of the growth axis.

GHRH + GHRP synergy and desensitization

The combination of Hexarelin with a GHRH analog (like CJC-1295) is in studies associated with stronger GH release than either component alone. At the same time, high receptor affinity leads to faster desensitization, which is why the literature recommends shorter cycles with breaks.

Note: The information is presented for scientific and informational purposes and is based on the pharmacological and preclinical literature. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.

Hexarelin profile at a glance

• Most potent synthetic GHRP secretagogue — the strongest GH pulses among the classic GHRPs
• GHS-R1a agonist + somatostatin inhibition — a dual mechanism that increases GH release
• Unique cardioprotection via the CD36 receptor — in studies independent of growth hormone
• Minimal effect on appetite — unlike GHRP-6
• Requires short cycles due to fast receptor desensitization
• Strong synergy with a GHRH analog (e.g. CJC-1295) — two separate receptors

All information provided refers to the pharmacological and preclinical literature on Hexarelin and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology.

Research dosing protocols

Due to its high potency and tendency toward desensitization, Hexarelin is used in studies in short cycles, subcutaneously:

• Subcutaneous (SC) administration, usually on an empty stomach; GH peak ~30 minutes after administration
• Cyclicity: the literature describes shorter cycles (e.g. 4–6 weeks) with breaks — to limit desensitization
• Dose precision: due to the high potency, accurate calculation of the amount is important
• Combined schedules: Hexarelin (GHRP) + GHRH analog (e.g. CJC-1295) for a synergistic effect

In GH-axis protocols, Hexarelin is sometimes combined with CJC-1295, and in regenerative protocols with BPC-157. These schedules come from the research literature and do not constitute a recommendation for self-administration.

Side effects and safety

In research observations, Hexarelin is described as well tolerated with correctly planned cycles. Side effects are usually mild and dose-dependent, and the key aspect specific to this molecule is receptor desensitization.

Most side effects are mild and reversible, and desensitization is limited through cyclicity. This information is scientific in nature and does not constitute an instruction for use.

Storage and reconstitution

Hexarelin is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.

• Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
• After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
• After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
• Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
• Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator — particularly important given Hexarelin's high potency.
• Homogenization: add the solvent slowly down the vial wall, without vigorous shaking — peptide bonds are sensitive to mechanical stress. Swirl gently, do not shake.

Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.

Frequently asked questions about Hexarelin

What exactly is Hexarelin?

It is a synthetic hexapeptide of the GHRP group and a ghrelin receptor agonist (GHS-R1a), described as the most potent growth hormone secretagogue. It stands out for its additional cardioprotective action via the CD36 receptor. The results come from the pharmacological and preclinical literature.

How fast does Hexarelin work?

Peak plasma GH concentrations are usually reached about 30 minutes after administration, which makes it one of the fastest-acting secretagogues.

How does it differ from Ipamorelin and GHRP-6?

Hexarelin is the most potent of the three and the only one to show cardioprotective action via CD36. Ipamorelin is the cleanest (minimal effect on other hormones), and GHRP-6 strongly stimulates appetite. Hexarelin also requires shorter cycles due to desensitization.

Can it be combined with other peptides?

Yes — it is classically combined with a GHRH analog, like CJC-1295 (two separate receptors, synergy), and in regenerative protocols with BPC-157.

How is Hexarelin stored and reconstituted?

The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.

Where to buy Hexarelin for research?

Peptology offers Hexarelin 5 mg as a research peptide with confirmed purity above 99% (HPLC/MS) and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.

Related peptides in the Peptology catalog

Researchers working with Hexarelin often also consider other GHRP secretagogues, GHRH analogs and regenerative peptides. Each of the products below has a certificate of purity above 99%:

See the full catalog: Recovery and anabolic peptides · Solutions for peptides · All peptides · Blog on peptide research

Laboratory reconstitution

Laboratory protocol — reconstitution, research protocols, storage

Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.

60-second protocol

Quick reference

What you need

Five rules for reconstitution

Calculating concentration

Storage

Four mistakes to avoid

Shipping information

🚚 Shipping information

• Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.

• Delivery with GLS to your address in 3–5 working days.

• Shipping costs €5 and is free from €50.

Frequently Asked Questions (FAQ)

❓ Frequently Asked Questions (FAQ)

In what form is Hexarelin supplied and how should it be stored?

As a lyophilised powder in a sealed 5 mg vial. Before reconstitution store it at room temperature, protected from light and moisture; after reconstitution keep it at +2 to +8 °C (up to 60 days with Peptide Matrix Water).

What purity does Hexarelin have and how is it tested?

Purity above 99%, confirmed by HPLC and mass spectrometry for every batch. The certificate of the current batch is shown in the “Laboratory Analysis” tab.

Is a prescription required?

No – the product is intended for research and laboratory use only.

Where can I buy Hexarelin in Europe and what does it cost?

You can buy Hexarelin in Europe online from Peptology, from 28,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.

Laboratory Analysis

Hexarelin - 5 mg - Batch - 0226 - Purity