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Epithalon
Epithalon 50 mg – Synthetic tetrapeptide (AEDG) for research
Peptology Ltd. · Peptides for skin, sleep and libido
Epithalon 50 mg – a synthetic tetrapeptide (Ala-Glu-Asp-Gly, AEDG) modelled on the pineal peptide epithalamin; a research peptide studied in telomerase and cellular-ageing models. Purity 99%+, HPLC/MS report for every batch.
📦 The product is in our EU warehouse – delivery within 3–5 working days.
89,00 € · In stock
For research use only / Not a medicine
| Purity | >99% |
|---|---|
| Method | HPLC + LC/MS |
| Laboratory | Analiza Białek |
| Batch | 0226 |
What is Epithalon (Epitalon) 50 mg?
Epithalon (Epitalon, Epithalamin) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, modeled on the natural pineal gland peptide. In the research literature it is described as an anti-aging compound — it is sometimes called the „longevity peptide" — studied for telomerase activation, regulation of melatonin production and cellular renewal.
Epithalon belongs to the category peptides for skin, sleep and libido. It combines two areas: regeneration/aging and sleep — through its effect on the pineal gland and melatonin it is related both to the hormone Melatonin and to the sleep neuropeptide DSIP.
It is a research compound — it is not a medicinal product and holds no registration for clinical use in the EU. The product offered by Peptology is a research-grade reagent, not intended to diagnose, slow aging or treat any conditions in humans.
In the version offered by Peptology, Epithalon is available in a 50 mg vial as a lyophilized peptide of high purity, confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.
Variant: Epithalon 50 mg
This page concerns a single dose variant — Epithalon 50 mg. Each vial contains 50 mg of lyophilized tetrapeptide. This is a large, „cycle-sized" amount — in research protocols Epithalon is usually used in 10-day cycles (once or twice a year), and a 50 mg vial is enough for a full cycle or several smaller series.
VIAL · 50 MG
Epithalon (tetrapeptide)
50 mg of lyophilized peptide — a large, cycle-sized vial, purity confirmed by CoA for every batch.
REFERENCE CONCENTRATION
~16.7 mg/mL (50 mg / 3 mL)
With a large dose, precisely calculate volumes in the calculator.
Epithalon is offered in the 50 mg variant. If you are researching a different sleep-regulation mechanism, check the neuropeptide DSIP (delta wave) or the hormone Melatonin (circadian rhythm).
How Epithalon works — research mechanisms
In the research literature, Epithalon is described as a peptide acting at several levels related to cellular renewal and the circadian rhythm. Below are the three most frequently studied elements.
TELOMERASE
Studied for telomerase activation — the enzyme associated with the maintenance of telomeres and cell viability.
MELATONIN / PINEAL GLAND
Modeled on the pineal gland peptide — studied in the context of melatonin regulation and the circadian rhythm.
CELLULAR RENEWAL
Studied in the context of DNA repair, antioxidant protection and immune system function.
Why Epithalon links „sleep" with „regeneration"
The pineal gland is a gland that produces melatonin and regulates the circadian rhythm. As an analog of the pineal gland peptide, Epithalon is studied simultaneously for sleep (melatonin) and cellular renewal (telomerase). This places it in the catalog at the intersection of „sleep" (like Melatonin and DSIP) and „regeneration".
It should be emphasized that claims of „slowing aging" come from research on the molecule (mainly preclinical and early clinical) and are not a confirmed effect of the research-grade product offered by Peptology.
Pharmacokinetics and pharmacodynamics (research framework)
Epithalon is a very short peptide (a tetrapeptide) with a „cycle" profile — used in series rather than continuously. The most important research features:
- Structure: synthetic tetrapeptide Ala-Glu-Asp-Gly (pineal gland peptide analog)
- Targets: telomerase, the pineal–melatonin axis, DNA repair mechanisms
- Schedule: typically 10-day cycles, repeated 1–2 times a year
- Profile: in studies described as well tolerated
- Reference concentration: 50 mg in 3 mL = ~16.7 mg/mL — the large dose requires a precise calculation
- Route of administration in protocols: most often subcutaneous, per the research protocol
Comparison: Epithalon vs DSIP vs Melatonin
In the skin/sleep/libido category, three compounds concern sleep and regeneration, but at different levels. The table below helps orient you to how Epithalon differs from two related products.
| Epithalon (this page) | DSIP | Melatonin | |
|---|---|---|---|
| Compound type | Tetrapeptide | Neuropeptide | Hormone |
| Main mechanism | Telomerase, pineal gland, melatonin | Sleep architecture (delta wave) | Circadian rhythm (when to sleep) |
| Main research area | Aging, regeneration + sleep | Deep sleep, stress (HPA) | Falling asleep, jet lag |
| Dose (this version) | 50 mg | 5 mg | 10 mg |
| Usage schedule | 10-day cycles (1–2 ×/year) | Daily or rotationally | In the evening, as needed |
Epithalon is a „cycle" regenerative-sleep peptide, DSIP acts on sleep depth, and Melatonin on its timing. This comparison is indicative in nature and does not constitute a recommendation for use.
Research areas for Epithalon
Epithalon has been studied for several decades, mainly in the context of cellular aging and biological rhythms. Below are the most frequently explored directions — all at the research stage, without confirmed indications for the research-grade product.
Telomeres and cellular aging
The most recognizable direction of research on Epithalon concerns telomerase activation and the maintenance of telomeres. In cellular models it was associated with an extension of cell viability. These are laboratory observations that should not be equated with „extending life" in humans.
Sleep and circadian rhythm
As an analog of the pineal gland peptide, Epithalon is studied for the regulation of melatonin production and improvement of the circadian rhythm — hence its presence in the „sleep" segment, alongside Melatonin and DSIP.
Immunity and biomarkers
In studies, observations appear regarding the effect of Epithalon on immune system function and selected biomarkers associated with aging. These are research directions, not confirmed therapeutic applications.
Note: The information is presented for scientific and informational purposes and is based on the preclinical literature and early studies. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.
Epithalon profile at a glance
- Pineal gland tetrapeptide (Ala-Glu-Asp-Gly) — the „longevity peptide" in the research literature
- Three studied areas: telomerase, the melatonin/pineal axis, cellular renewal
- Links sleep with regeneration — at the intersection of the „sleep" and „aging" segments
- Cycle schedule: typically 10 days, 1–2 times a year
- Related sleep compounds: DSIP and Melatonin; skin regeneration: GHK-Cu
- Every batch with CoA and confirmed laboratory purity
All information provided concerns research literature on Epithalon and should not be interpreted as a promise of effect (including „slowing aging"), an instruction for use or a claim about the effect of the research-grade product offered by Peptology.
Research dosing protocols
Important: The information below describes schedules used in research on Epithalon. It is provided for scientific and informational purposes and does not constitute a recommendation for individual use, medical advice or administration instructions. The research-grade Epithalon offered by Peptology is not a registered medicine.
In research protocols, Epithalon is usually administered after reconstitution of the lyophilizate, most often subcutaneously, in a cycle schedule:
- A typical research cycle lasts about 10 days and is sometimes repeated 1–2 times a year
- The 50 mg vial allows a full cycle or several smaller series to be covered
- With a high vial content, a precise volume calculation is especially important — use the peptide calculator
- Maximum 3 mL of solvent per vial (50 mg / 3 mL ≈ 16.7 mg/mL)
In combination protocols, Epithalon is sometimes combined with regenerative peptides (like BPC-157 or GHK-Cu) in regeneration research. These schedules come from the research literature and do not constitute a recommendation for self-administration.
Side effects and safety
In research observations, Epithalon is described as well tolerated. The reported side effects are rare and mild. The data concern research on the molecule.
Rare (mild)
- Headache or slight dizziness (first days)
- Transient drowsiness
- Injection-site reaction
Tolerability profile
- Well tolerated in observations
- The cycle schedule limits exposure
- No serious effects reported
To consider
- Very rarely, allergic reactions (rash)
- No clinical data for the research-grade product
- Hypersensitivity to components
Most reported symptoms are mild and transient, and the cycle schedule limits exposure. This information is scientific in nature and does not constitute an instruction for use.
Storage and reconstitution
Epithalon is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.
- Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
- After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
- After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
- Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
- Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
- Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.
Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.
Frequently asked questions about Epithalon
What exactly is Epithalon?
It is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled on the pineal gland peptide, studied for telomerase activation, melatonin regulation and cellular renewal. It is sometimes called the „longevity peptide". The results come from the research literature.
How does Epithalon differ from DSIP and melatonin?
Epithalon combines regeneration (telomerase) with sleep (pineal gland/melatonin) in a cycle schedule. DSIP acts on sleep depth (delta wave), and Melatonin on the circadian rhythm (sleep timing).
How is Epithalon stored and reconstituted?
The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.
Where to buy Epithalon for research?
Peptology offers Epithalon (50 mg) as a research peptide of confirmed purity with independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.
Related products in the Peptology catalog
Researchers working with Epithalon often also consider related sleep-regulating compounds and regenerative peptides. Each of the products below has a certificate of purity (CoA):
DSIP
Sleep neuropeptide — sleep architecture (delta wave)
Melatonin
Circadian rhythm regulator — sleep timing
GHK-Cu
Copper peptide — regeneration and skin condition
BPC-157
Repair peptide — common in regeneration protocols
Melanotan 2 (MT-2)
Pigmentation + libido (melanocortins)
Peptide Matrix Water™
Stabilizing solution for reconstitution
See the full catalog: Peptides for skin, sleep and libido · Peptides for energy and regeneration · Solutions for peptides · Blog on peptide research
Research warning: Epithalon (Epitalon) is offered exclusively for scientific research and in vitro purposes. It is not a medicinal product, is not approved for use in humans or animals, and does not replace medical advice. It is not intended to slow aging or treat any conditions. All information comes from research literature and is provided for scientific and informational purposes; it does not constitute a claim about the effect of the research-grade product offered by Peptology.
Laboratory reconstitution
Laboratory protocol — reconstitution, research protocols, storage
Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.
60-second protocol
1. SOLVENT
2. RECONSTITUTION
Add the solvent down the side of the vial, without shaking, wait 10–15 min.
3. CALCULATION
Calculator → concentration mg/mL
4. STORAGE
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water
Quick reference
| Parameter | Value |
|---|---|
| Form | Lyophilized powder |
| Solvent | Peptide Matrix Water |
| Reconstitution volume | 1–3 mL — maximum 3 mL (capacity of the standard vial) |
| Storage before reconstitution | Room temperature, protected from direct light (refrigeration not required) |
| After reconstitution | Up to 60 days at +2 °C to +8 °C with Peptide Matrix Water |
What you need
Precision pipette
Calibrated, 100–1000 µL — for accurately measuring the volume of solvent added to the vial.
70% alcohol swabs
Two swabs — to disinfect the peptide vial and the solvent vial.
Stabilized solvent for lyophilized peptides. Why this one.
Five rules for reconstitution
| ✅ Correct | ❌ Mistake |
|---|---|
| Disinfect the vial caps and the work surface with 70% alcohol; wear gloves | Working without disinfection |
| Add the solvent slowly along the vial wall | Direct jet onto the powder — foaming and denaturation |
| Gentle rolling between the palms | Shaking — foam, which denatures peptides |
| 10–15 minutes waiting at room temperature | Mechanical mixing or heating |
| Visual check: clear, particle-free | Working with a cloudy or discolored solution |
Calculating concentration
⚠️ Maximum 3 mL solvent. The standard vial does not accommodate larger volumes — do not exceed during reconstitution.
- Concentration (mg/mL) = mg in the vial ÷ mL of solvent
- Volume per sample (mL) = amount per sample (mg) ÷ concentration (mg/mL)
- 1 mg/mL = 1 µg/µL · 1 mL = 1000 µL
Reconstitution per vial — solvent: Peptide Matrix Water. Concentration after adding the solvent (1 mg/mL = 1 µg/µL):
| Vial | + 1 mL | + 2 mL | + 3 mL |
|---|---|---|---|
| 50 mg | 50 mg/mL | 25 mg/mL | 16.67 mg/mL |
👉 For any vial and solvent volume — use the calculator. It calculates the concentration (mg/mL, µg/µL) and the volume per sample (mL, µL).
Storage
BEFORE RECONSTITUTION
Room temperature, protected from direct light, in original packaging. Refrigerator not required.
AFTER RECONSTITUTION
+2 °C to +8 °C, up to 60 days with Peptide Matrix Water. Discard any remainder after this period.
FREEZING
Not recommended. Freeze/thaw cycles degrade peptide structure.
Four mistakes to avoid
1. Shaking "to dissolve faster"
Foam = denaturation. Only gentle rolling between the palms.
2. Inappropriate solvent
For peptide stability use only sterile, specially formulated solvent — recommended Peptide Matrix Water.
3. Ignoring slight turbidity
Not fully clear = the sample does not meet the criteria for use.
4. Taking it out of the refrigerator "for an hour–two"
Short exposures add up and compromise stability.
Research status: All Peptology products are intended for laboratory and research use only. They are not medicinal products, not approved for human or veterinary use and do not substitute medical advice. The described protocol is standard laboratory practice for working with lyophilized peptides.
Shipping information
🚚 Shipping information
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Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.
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Delivery with GLS to your address in 3–5 working days.
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Shipping costs €5 and is free from €50.
Frequently Asked Questions (FAQ)
In what form is Epithalon supplied and how should it be stored?
It is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store the unopened vial dry and protected from light, ideally at 2–8 °C. After laboratory reconstitution, keep the solution at 2–8 °C and use it within the period stated in the “Laboratory reconstitution” tab (up to 60 days with Peptide Matrix Water).
What purity does Epithalon have and how is it tested?
Every batch has a purity of 99% or higher, confirmed by HPLC and mass spectrometry (MS) and documented in a certificate of analysis (CoA). The report for the current batch is shown in the “Laboratory Analysis” tab.
Is a prescription required?
No. The product is for laboratory and research use only.
Where can I buy Epithalon in Europe and what does it cost?
You can buy Epithalon in Europe online from Peptology, from 89,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.
Laboratory Analysis
Epithalon - 50 mg - Batch - 0226 - Purity
