PT-141 (Bremelanotide) 10 mg – Melanocortin receptor agonist

What is PT-141 (Bremelanotide) 10 mg?

PT-141 (Bremelanotide) is a synthetic peptide that is a derivative of Melanotan II and an agonist of the melanocortin receptors — mainly MC4R (and MC3R). Its distinguishing feature is a central mechanism: unlike PDE5-type compounds (such as sildenafil), PT-141 does not act by dilating blood vessels, but stimulates neural pathways in the brain associated with libido and sexual arousal.

PT-141 belongs to the category peptides for skin, sleep and libido — in the „libido" segment. It is the most targeted of the three melanocortin peptides in the catalog: it arose as a metabolite of Melanotan 2 (MT-2), but unlike it (and unlike the „skin" MT-1) it acts narrowly on MC4R, without a marked pigmentation effect.

In the version offered by Peptology, PT-141 is available in a 10 mg vial as a lyophilized peptide with purity ≥ 99%, confirmed by independent laboratory analysis (CoA for every batch). The product is intended exclusively for scientific research and in vitro applications.

Variant: PT-141 10 mg

This page concerns a single dose variant — PT-141 10 mg. Each vial contains 10 mg of lyophilized peptide. This is the standard amount for research protocols on libido — sufficient for a series of „as-needed" administrations (max. about 3 times a week in the described schedules), at small unit doses.

PT-141 is offered exclusively in the 10 mg variant. If you are interested in a melanocortin peptide with a broader profile (pigmentation + libido), check Melanotan 2 (MT-2) 10 mg, and for the „skin" variant — Melanotan 1 (MT-1) 10 mg.

How PT-141 works — a central mechanism

In the research literature, PT-141 is described as a melanocortin agonist acting at the level of the central nervous system. Below are the three most frequently studied elements.

Why the central mechanism sets PT-141 apart

Most known compounds supporting sexual function (PDE5 inhibitors) act vascularly — improving blood flow. PT-141 represents a different mechanism: it directly stimulates the neural arousal pathways in the brain via the MC4R receptors. That is why it is also studied where the vascular approach is sometimes ineffective, and in women (in the context of HSDD), not only in men.

As a derivative of MT-2, PT-141 retained affinity for MC4R (libido), while almost completely losing activity on MC1R (pigmentation). These data come from research on bremelanotide and do not constitute a claim about the effect of the research-grade product offered by Peptology.

Pharmacokinetics and pharmacodynamics (research framework)

PT-141 is a peptide with a relatively rapid onset of action and a short window of activity. The most important research features:

• Class: synthetic melanocortin peptide (MT-2 derivative), MC4R/MC3R agonist
• Mechanism: central (neural), without vasodilatory action
• Onset of action: in observations usually 30–60 min after administration
• Half-life: about 2.7 h — the action lasts a few hours
• Schedule: used „as needed", not daily (max. about 3 times a week in the described protocols)
• Route of administration in protocols: most often subcutaneous, per the research protocol

Comparison: PT-141 vs MT-2 vs MT-1

All three peptides from the skin/sleep/libido category are melanocortin agonists, but they differ in receptor selectivity and main research area. PT-141 is the narrowest — targeted at libido. The table below helps orient you to the differences.

PT-141 is a „narrow specialist" in libido (MC4R, no pigmentation). MT-2 combines pigmentation with libido, and MT-1 is „skin"-focused. This comparison is indicative in nature and does not constitute a recommendation for use.

Research data on PT-141 / bremelanotide

Bremelanotide is one of the few melanocortin peptides studied extensively in clinical trials. Below are the most important directions — all concern the molecule, not the research-grade product.

Libido and sexual function

The main direction of research on PT-141 concerns sexual arousal and desire through the activation of MC4R. Bremelanotide was studied in both women (HSDD) and men (erectile dysfunction), including where the vascular approach is sometimes insufficient.

Central vs vascular mechanism

In studies, PT-141 was distinguished as a compound acting centrally (neurally), without a significant effect on blood pressure typical of PDE5 inhibitors. This sets it apart mechanistically from the „classic" compounds for sexual function.

Note: The information is presented for scientific and informational purposes and is based on the literature on bremelanotide. It does not constitute medical advice, a recommendation for use or a claim about the effect of the research-grade product offered by Peptology.

PT-141 profile at a glance

• Centrally acting MC4R agonist — neural arousal pathways, not the blood vessels
• The narrowest profile of the three melanocortins — targeted at libido, minimal pigmentation
• A derivative of MT-2 — retained affinity for MC4R, lost activity on MC1R
• Rapid onset (~30–60 min), action for a few hours (half-life ~2.7 h)
• Every batch with CoA and purity ≥ 99%

All information provided concerns research literature on PT-141 / bremelanotide and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology.

Research dosing protocols

In research protocols, PT-141 is usually administered after reconstitution of the lyophilizate, most often subcutaneously:

• „As-needed" administration, usually in advance (action observed after ~30–60 min)
• Not a daily schedule — in the described protocols max. about 3 times a week
• After reconstituting 10 mg in 1 mL the concentration is 10 mg/mL — calculate precise volumes and units in the peptide calculator
• Maximum 3 mL of solvent per vial

In the research literature, PT-141 is sometimes considered together with the vascular mechanism (PDE5), as a complementary approach. These schedules come from studies and do not constitute a recommendation for self-administration or combination.

Side effects and safety

In studies of bremelanotide, side effects are usually mild and transient, most often at the start of use. The data concern research on the molecule.

The most frequently reported effect is mild nausea, usually resolving over time or after a dose reduction. This information is scientific in nature and does not constitute an instruction for use.

Storage and reconstitution

PT-141 is supplied as a lyophilized (freeze-dried) powder in a vial. In lyophilized form it is stable at room temperature, protected from light and moisture — refrigeration before reconstitution is not mandatory. After reconstitution, stability depends on the solvent used, with Peptide Matrix Water™ significantly extending the peptide's lifespan.

• Before reconstitution: room temperature, in the original packaging, protected from light and moisture. A refrigerator is not mandatory.
• After reconstitution with Peptide Matrix Water™: stability in the refrigerator +2 °C to +8 °C for up to 60 days under appropriate laboratory conditions — the stabilizing formula extends the peptide's lifespan relative to standard solvents.
• After reconstitution with bacteriostatic or sterile water: stability in the refrigerator +2 °C to +8 °C for up to 28 days under appropriate conditions. Do not refreeze the reconstituted solution.
• Reconstitution: in a laboratory setting, Peptide Matrix Water™, bacteriostatic water or sterile water for injection is usually used, depending on the protocol.
• Volume: maximum 3 mL of solvent (capacity of a standard vial). For a precise calculation of volume and units, use the peptide calculator.
• Homogenization: add the solvent slowly down the vial wall, without vigorous shaking, then wait 10–15 min. Swirl gently, do not shake.

Laboratory tip: With your order, you can add Peptide Matrix Water™ to the cart — a stabilizing solution designed for working with reconstituted research peptides. More in the article Bacteriostatic water vs acetic acid vs matrix water.

Frequently asked questions about PT-141

What exactly is PT-141?

It is a synthetic melanocortin peptide (bremelanotide), a derivative of MT-2 and an agonist of the MC4R receptor. Unlike PDE5 inhibitors, it acts centrally (in the brain), not by dilating vessels. In research it is associated with libido and sexual function. The results come from the research literature.

Is PT-141 a medicine?

No. The product offered by Peptology is a research reagent (research-grade), not a medicine.

How does PT-141 differ from MT-2?

PT-141 is a metabolite of MT-2 narrowly targeted at MC4R — it acts on libido, but almost without a pigmentation effect. MT-2 is a „broader" molecule (pigmentation + libido), and MT-1 acts mainly on the skin.

How quickly and how long does PT-141 work?

In observations, the action appears after ~30–60 minutes of administration and lasts a few hours (half-life ~2.7 h). That is why in research protocols it is administered „as needed", not daily.

How is PT-141 stored and reconstituted?

The lyophilized vial is stored at room temperature, protected from light and moisture. After reconstitution, stability depends on the solvent: with Peptide Matrix Water™ — up to 60 days in the refrigerator +2 °C to +8 °C; with bacteriostatic or sterile water — up to 28 days. Avoid refreezing.

Where to buy PT-141 for research?

Peptology offers PT-141 (10 mg) as a research peptide with confirmed purity ≥ 99% and independent laboratory analysis for every batch. Fast shipping, discreet packaging and certificates of purity with the product. For scientific background, also see the article Peptides — what they are, how they work, main categories and safety profile.

Related products in the Peptology catalog

Researchers working with PT-141 often also consider related melanocortin peptides and other compounds from the skin/sleep/libido category. Each of the products below has a certificate of purity (CoA):

See the full catalog: Peptides for skin, sleep and libido · Peptides for energy and regeneration · Solutions for peptides · Blog on peptide research

Molecule identity

Laboratory reconstitution

Laboratory protocol — reconstitution, research protocols, storage

Standardized protocol applicable to all research peptides in the Peptology catalogue. To calculate the solution concentration (mg/mL) for each vial, use the peptide reconstitution calculator.

60-second protocol

Quick reference

What you need

Five rules for reconstitution

Calculating concentration

Storage

Four mistakes to avoid

Shipping information

🚚 Shipping information

• Products in our warehouse – orders placed by 15:00 on working days are dispatched the same day, later orders on the next working day.

• Delivery with GLS to your address in 3–5 working days.

• Shipping costs €5 and is free from €50.

Frequently Asked Questions (FAQ)

In what form is PT-141 supplied and how should it be stored?

It is supplied as a lyophilized (freeze-dried) powder in a sealed vial. Store the unopened vial dry and protected from light, ideally at 2–8 °C. After laboratory reconstitution, keep the solution at 2–8 °C and use it within the period stated in the “Laboratory reconstitution” tab (up to 60 days with Peptide Matrix Water).

What purity does PT-141 have and how is it tested?

Every batch has a purity of 99% or higher, confirmed by HPLC and mass spectrometry (MS) and documented in a certificate of analysis (CoA). The report for the current batch is shown in the “Laboratory Analysis” tab.

Is a prescription required?

No – the product is supplied for research use only.

Where can I buy PT-141 in Europe and what does it cost?

You can buy PT-141 in Europe online from Peptology, from 39,00 €. Delivery with GLS in 3–5 working days. Shipping is free from 50,00 €. Payment by card. Purity 99%+, with an HPLC report for every batch.

Laboratory Analysis

PT-141 - 10 mg - Batch - 0126 - Purity